129664-75-1Relevant academic research and scientific papers
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
Ito, Chihiro,Itoigawa, Masataka,Kanematsu, Tetsufumi,Imamura, Yuuki,Tokuda, Harukuni,Nishino, Hoyoku,Furukawa, Hiroshi
, p. 902 - 909 (2008/03/27)
Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
A THEORETICAL AND EXPERIMENTAL INVESTIGATION OF Z,E STEREOISOMERISM IN SOME SIMPLE LIGNIN p-QUINONE METHIDES
Konschin, Henrik,Jakobsons, Juris,Shevchenko, Sergey M.
, p. 231 - 244 (2007/10/02)
On the basis of 3-21G ab initio, AM1 semiempirical and molecular mechanics calculations, the structures of the E and Z stereoisomers of the simplest lignin model p-quinone methides, 2-methoxy-4-ethylidene-2,5-cyclohexadiene-1-one (1) and 2-methoxy-4-(2-pr
PHYSICOCHEMICAL CHARACTERISTICS, ELECTRONIC STRUCTURE, AND REACTIVITY OF THE MODEL p-QUINONE METHIDES OF LIGNIN
Shevchenko, S. M.,Semenov, S. G.,Evstigneev, E. I.,Pranovich, A. V.,Gindin, V. A.
, p. 1679 - 1688 (2007/10/02)
The simplest p-quinone methides which adequately model the reactive fragments of the lignin macromolecule, i.e., 2-methoxy-4-propylidene>-2,5-cyclohexadien-1-one (I) and 2-methoxy-4(2-propenylidene)-2,5-cyclohexadien-1-
