129666-25-7

Basic information

• Product Name: 1H-3-Benzazepine, 2,3,4,5-tetrahydro-3-methyl-1-phenyl-
• CAS NO: 129666-25-7
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• Mol File: 129666-25-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-3-Benzazepine, 2,3,4,5-tetrahydro-3-methyl-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-3-Benzazepine, 2,3,4,5-tetrahydro-3-methyl-1-phenyl-(129666-25-7)
• EPA Substance Registry System: 1H-3-Benzazepine, 2,3,4,5-tetrahydro-3-methyl-1-phenyl-(129666-25-7)

Safety Data

• Hazardous Substances Data: 129666-25-7(Hazardous Substances Data)

Upstream product

• 144436-97-5 (1S,2R)-2-Methyl-1-phenyl-2-trimethylsilanylmethyl-1,2,3,4-tetrahydro-isoquinolinium; iodide 
• 50-00-0 formaldehyd 
• 20390-68-5 (+/-)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 1612-65-3 2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 1240503-21-2 2-cyanomethyl-2-methyl-1,2,3,4-tetrahydroisoquinolinium chloride 
• 171196-38-6 2-cyano-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 34583-80-7 3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 108-90-7 chlorobenzene 
• 1147090-61-6 2-(N-methyl-N-(2-phenylethyl)amino)-1-phenylethyl N',N'-diisopropylcarbamate 

Relevant articles and documents

Aryne-Mediated Arylation of the 3-Benzazepine Scaffold: One-Pot Synthesis of 1-Aryl-3-methyl-2,3,4,5-tetrahydro-1 H -3-benzazepines

The coupling of β-amino carbanions derived from 3-benzA"azeA"pines with in situ generated arynes has been demonstrated as a convenient route for the direct synthesis of a variety of 1-aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines, including the biologically active drug molecule SCH 12679.

Direct syntheses of 4-aryl-1,2,3,4-tetrahydroisoquinolines and 1-aryl-2,3,4,5-tetrahydro-3-benzoazepines via hydroamination of enol carbamates

An efficient and simple procedure for the syntheses of 4-aryl-1,2,3,4-tetrahydroisoquinolines and 1-aryl-2,3,4,5-tetrahydro-3-benzoazepines has been developed. The approach uses easily available starting materials and requires just three steps. The hydroamination of an enol carbamate is the key step. This general and direct method has been applied to the total synthesis of the natural alkaloid cherylline and to biologically active 3-benzoazepines as well.