1296665-00-3

Upstream product

• 4136-95-2 2,4,6-trichlorobenzoyl chloride 
• 108-94-1 cyclohexanone 
• 4767-03-7 2,2-bis(hydroxymethyl)propionic acid 
• 1670-47-9 1,1-diethoxycyclohexane 

Downstream Products

• 162635-04-3 temsirolimus 
• 343261-52-9 temsirolimus 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES

The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.

PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES

The invention relates to processes for the preparation of compound of CCI-779 having the Formula (I), which is useful as an antineoplastic agent. The invention further relates to certain novel intermediates useful in the preparation of compound of CCI-779 and processes for their preparation. The invention also relates to pharmaceutical compositions that include the compound of CCI-779, prepared according to the processes disclosed herein.