129670-13-9

Basic information

• Product Name: 1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione
• Synonyms: 1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione
• CAS NO: 129670-13-9
• Molecular Weight: 306.318
• Mol File: 129670-13-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione(129670-13-9)
• EPA Substance Registry System: 1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione(129670-13-9)

Safety Data

• Hazardous Substances Data: 129670-13-9(Hazardous Substances Data)

Upstream product

• 93-02-7 2,5-dimethoxybenzaldehyde 
• 3027-05-2 N,N'-diacetylpiperazin-2,5-dione 
• 114912-57-1 1-acetyl-3-(2,5-dimethoxybenzylidene)piperazine-2,5-dione 

Downstream Products

• 1334306-29-4 6-benzyloxymethyl-2-isopropoxycarbonyl-7,10-dimethoxy-2,3,6,11-tetrahydropyrazino[1,2-b]isoquinoline-4-one 
• 1334306-30-7 6-benzyloxymethyl-2-isopropoxycarbonyl-7,10-dimethoxy-1,2,3,6-tetrahydropyrazino[1,2-b]isoquinolin-4-one 
• 592529-83-4 1-acetyl-3-(2,5-dimethoxy-benzyl)-4-(1-methoxy-ethyl)-piperazine-2,5-dione 

Relevant articles and documents

Short stereocontrolled synthesis of trans and cis-tetrahydro-pyrazinoisoquinolinediones

Addition of aldehyde dimethyl acetals (here acetaldehyde) to unisolated O-trimethylsilyl derivatives of 1-acetyl-3-arylmethylpiperazine-2,5-diones (here 2,5-dimethoxyphenyl), in the presence of TMSOTf as the catalyst, gave nearly quantitatively the corres

Improvements in aldol reactions with diketopiperazines

Precipitation of products by using dichloromethane as solvent permits an efficient aidol-type reaction between 1,4-diacetyl-2,5-piperazinedione and aromatic aldehydes catalyzed by KtBuO/tBuOH independently of the electrophilic character of the aryl ring. A simple method to obtain 3-methyl-2,4,5-trimethoxybenzaldehyde is also reported.