129673-17-2Relevant articles and documents
Thiol inhibitors of endothelin-converting enzyme
Deprez, Pierre,Guillaume, Jacques,Dumas, Jacques,Vevert, Jean-Paul
, p. 2317 - 2322 (2007/10/03)
Synthesis and structure activity relationships of a series of thiol inhibitors of the endothelin-converting enzyme (ECE) are presented. Optimisation of the stereochemistry as well as of the P'1 and P'2 residues led to inhibitors with similar potency to that of phosphoramidon.
Aminobenzoic and aminocyclohexanecarboylic acid compounds, compositions, and their method of use
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, (2008/06/13)
Compounds of the formula inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.