1296863-89-2Relevant academic research and scientific papers
Synthesis of 1,4-Dicarbonyl Compounds by Visible-Light-Mediated Cross-Coupling Reactions of α-Chlorocarbonyls and Enol Acetates
Liu, Qiang,Wang, Rui-Guo,Song, Hong-Jian,Liu, Yu-Xiu,Wang, Qing-Min
, p. 4391 - 4396 (2020/09/21)
Herein, we report a protocol for visible-light-mediated radical coupling reactions of α-chloroketones and enol acetates to afford 1,4-dicarbonyl compounds, which are important precursors and intermediates in organic synthesis. The reaction involves photoredox-catalyzed activation of the α-chloroketone upon photoelectron transfer, carbon–chlorine bond cleavage, and coupling of the resulting radical with the carbon–carbon double bond of the enol acetate. This mild protocol has a wide substrate scope and moderate to good yields. (Figure presented.).
Preparation of γ-oxo esters by Staudinger reduction of β-azidocyclopropane esters
Gu, Peiming,Wu, Xiu-Ping,Su, Yan,Xue, Ping,Li, Xue-Qiang,Gong, Bo-Lin,Li, Rui
supporting information, p. 4957 - 4959 (2013/09/02)
An efficient and practiced procedure for the preparation of γ-oxo esters from the β-azidocyclopropane esters has been developed. Ph 3P was proven to be a good promoter in THF/H2O, and 11 γ-oxo esters were prepared in 73-99% yields under mild and neutral conditions.
Formation of five-membered cyclic orthoesters from tribromides with participation of a neighboring carbonyl group
Gururaja, Guddeangadi N.,Mobin, Shaikh M.,Namboothiri, Irishi N. N.
, p. 2048 - 2052 (2011/05/16)
The Mg-mediated conjugate addition of bromoform to enones followed by alcoholysis of the resulting keto tribromides proceeds through an unusual course, affording cyclic orthoester (dihydrofuran) intermediates under neutral workup conditions. However, acid
