1296866-33-5

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 100132-60-3 (S)-2-(toluene-4-sulfonamido)propan-1-ol 
• 106-95-6 allyl bromide 
• 4816-81-3 p-tosyl-L-alanine 
• 73270-63-0 N-Allylalanine methyl ester 

Downstream Products

• 1393751-21-7 4-methyl-N-(((2S,5S)-5-methyl-4-tosylmorpholin-2-yl)methyl)benzenesulfonamide 
• 1393751-38-6 N-(((2S,5S)-5-methyl-4-tosylmorpholin-2-yl)methyl)benzamide 
• 1393751-39-7 N-(((2R,5S)-5-methyl-4-tosylmorpholin-2-yl)methyl)benzamide 
• 1352166-11-0 C₂₀H₂₅NO₅S₂ 
• 1352166-21-2 C₂₀H₂₅IN₂O₂S 
• 1352166-16-5 C₂₀H₂₆N₂O₂S 
• 1352166-03-0 C₁₃H₁₈INO₃S 
• 1296866-39-1 3,6-dimethyl-4-(toluene-4-sulfonyl)-3,4-dihydro-2H-[1,4]oxazine 

Relevant academic research and scientific papers

Aryl λ3-Iodane-Mediated 6-exo-trig Cyclization to Synthesize Highly Substituted Chiral Morpholines

A mild and efficient transition metal-free approach has been developed for the synthesis of highly substituted chiral morpholines from alkenols by amino acid-derived iodine(III) reagents via a 6-exo-trig cyclization. The key features of this work include

Stereoselective synthesis of morpholines via copper-promoted oxyamination of alkenes

A new copper(II) 2-ethylhexanoate-promoted addition of an alcohol and an amine across an alkene (oxyamination) is reported. The alcohol addition is intramolecular, while coupling with the amine occurs intermolecularly. Several 2-aminomethyl morpholines we

I2-mediated diversity oriented diastereoselective synthesis of amino acid derived trans-2,5-disubstituted morpholines, piperazines, and thiomorpholines

Diastereoselective trans-2,5-disubstituted amino acids derived diverse morpholines, piperazines and thiomorpholines were prepared in 30 min-1 h with high yields through iodine-mediated 6-exotrig type cyclization from a single common synthetic intermediate. The displacement of iodine with hydride ion gave a methyl substituent at the 2-position of morpholines which provides an additional opportunity for diversity oriented nucleophilic substitution on the rings as well as incorporation of substituents at the 5-position from amino acids constituents.