1296868-02-4Relevant articles and documents
Inclusion of aliphatic alcohols in pockets of (S)-threonyl-(S)- phenylglycine using grinding method
Akazome, Motohiro,Toma, Shusaku,Horiguchi, Tatsunori,Megumi, Ken,Matsumoto, Shoji
, p. 2844 - 2848 (2011/05/06)
Inclusion compounds of a dipeptide, (S)-threonyl-(S)-phenylglycine (Thr-Phg), with several aliphatic alcohols were easily prepared by grinding them in a mortar. Thr-Phg molecules arranged in antiparallel to construct a sheet, and guest alcohols were accommodated in a chiral pocket between the sheets. 3-Butyn-2-ol and 2-butanol were included with moderate enantioselectivity, 57% ee (R) and 49% ee (R), respectively. The role of the hydroxy group of Thr-Phg is not only to construct the unique pocket but also to capture guest alcohols by hydrogen bonding.