129705-29-9 Usage
Uses
Used in Pharmaceutical Industry:
(2S,5S)-2,5-dimethyl-1-phenylphospholane is used as a chiral ligand for the synthesis of enantioselective pharmaceutical compounds. Its ability to control the stereochemistry of chemical reactions is crucial for producing the desired enantiomer in drug development, ensuring the efficacy and safety of the final product.
Used in Chemical Synthesis:
(2S,5S)-2,5-dimethyl-1-phenylphospholane is used as a catalyst in various organic reactions, such as hydrogenation, allylation, and cycloaddition. Its chiral structure allows for the selective formation of chiral products, which is essential in creating enantioenriched compounds for a range of applications, including the production of specialty chemicals and agrochemicals.
Used in Research and Development:
(2S,5S)-2,5-dimethyl-1-phenylphospholane is utilized in academic and industrial research settings to explore new methods in asymmetric catalysis and to develop novel enantioselective synthetic pathways. Its unique properties make it an important tool for advancing the understanding of stereochemistry and its applications in chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 129705-29-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,7,0 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 129705-29:
(8*1)+(7*2)+(6*9)+(5*7)+(4*0)+(3*5)+(2*2)+(1*9)=139
139 % 10 = 9
So 129705-29-9 is a valid CAS Registry Number.
129705-29-9Relevant academic research and scientific papers
PROCESS FOR PREPARING BISPHOSPHOLANE LIGANDS
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Page/Page column 12, (2008/06/13)
The present invention is directed at a process for preparing enantiomerically enriched compounds of the general formula (I). Compounds of the type shown are employed in catalyst systems.
Chiral tridentate bis(phospholane) ligands
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, (2008/06/13)
Chiral tridentate bis(phospholanes) which coordinate as ligands in a meridinal fashion on an octahedral metal or which coordinate in square-planar environments are provided with a method for their preparation.
New chiral phospholanes; synthesis, characterization, and use in asymmetric hydrogenation reactions
Burk,Feaster,Harlow
, p. 569 - 592 (2007/12/18)
We describe the practical synthesis of enantiomerically pure trans-2,5-disubstituted-1-phenylphospholanes which are then employed in the preparation of a new series of C2-symmetric bis- and C3-symmetric tris(phospholane) ligands. A versatile three-step route to the important chiral 1,4-diol intermediates, used in the phosphine syntheses, is outlined. Rhodium complexes bearing the new phosphine ligands were prepared and shown to act as efficient catalyst precursors for the enantioselective hydrogenation of various unsaturated substrates.
