129724-43-2

Basic information

• Product Name: 2',4'-Dihydroxy-3',6'-dimethoxychalcone
• Synonyms: 1-(2,4-Dihydroxy-3,6-diMethoxyphenyl)-3-phenylprop-2-en-1-one
• CAS NO: 129724-43-2
• Molecular Formula: C₁₇H₁₆O₅
• Molecular Weight: 300
• Mol File: 129724-43-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2',4'-Dihydroxy-3',6'-dimethoxychalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-Dihydroxy-3',6'-dimethoxychalcone(129724-43-2)
• EPA Substance Registry System: 2',4'-Dihydroxy-3',6'-dimethoxychalcone(129724-43-2)

Safety Data

• Hazardous Substances Data: 129724-43-2(Hazardous Substances Data)

Usage

General Description

2',4'-Dihydroxy-3',6'-dimethoxychalcone is a compound belonging to the chalcone family of chemicals, which are known for their diverse biological activities. This particular compound has been studied for its potential pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer effects. It is found in certain plant species, where it is thought to play a role in the plant's defense mechanisms. Research has also suggested that 2',4'-Dihydroxy-3',6'-dimethoxychalcone may have potential therapeutic applications in the treatment of various diseases, making it a subject of interest for further investigation in the field of pharmaceutical development.

Upstream product

• 87-66-1 2-hydroxyresorcinol 
• 55020-64-9 1,2,3-tris-benzyloxybenzene 
• 6625-45-2 2,6-bis-benzyloxy-[1,4]benzoquinone 
• 42528-81-4 2,6-bis-benzyloxy-benzene-1,4-diol 
• 6274-74-4 2,6-dibenzyloxy-1,4-dimethoxybenzene 
• 20032-42-2 2,5-dimethoxyresorcinol 
• 102-92-1 cinnamoyl chloride 
• 99-24-1 methyl galloate 
• 24093-81-0 methyl 3,5-dihydroxy-4-methoxybenzoate 
• 13326-69-7 methyl 3,5-bis(benzyloxy)-4-methoxybenzoate 
• 27229-56-7 [3,5-bis(benzyloxy)-4-methoxyphenyl]methanol 
• 13326-72-2 3,5-bis(benzyloxy)-4-methoxybenzaldehyde 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 3316-54-9 7-hydroxy-5,8-dimethoxyflavone 
• 1969289-10-8 (+)-celosine 
• 1969289-10-8 (-)-celosine 
• 632-85-9 wogonin 

Relevant articles and documents

Isolation, structure elucidation, and KDD study of (-)-Celosine, a new skeleton with potent anti-atherosclerosis activity

Natural (-)-Celosine was isolated as a novel endocyclicditerpene with an unprecedented skeleton from Celosia cristata L. Its structure was established by comprehensive 1D and 2D NMR spectroscopic analysis in combination with single-crystal X-ray crystallographic diffraction of synthesized (+)-Celosine. (-)-Celosine was expected to have an anti-atherosclerotic activity in vivo, and myeloperoxidase (MPO) expression may be the mechanism underlying this anti-atherosclerotic activity.

Synthesis, evaluation and quantitative structure–activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents

A novel series of 49 wogonin derivatives were synthesized by introducing group at 7-, 8- or B ring of wogonin. The cytotoxic activities against HepG2, A549 and BCG-823 cancer cell lines were also investigated in vitro. Several of them showed obvious cytotoxic activities and compound 3h possessed the highest potency against HepG2, A549, and BCG-823 with IC50 values of 1.07 μM, 1.74 μM and 0.98 μM, respectively. A quantitative structure-activity relationship (QSAR) study of these synthetic derivatives as well as wogonin indicated that high solubility and low octanol/water partition coefficient are favorable, and excessive electrostatic properties and refractivity are unfavorable for the cytotoxic activities of these wogonin derivatives. These findings and results provide a base for further investigations.