1297285-52-9Relevant academic research and scientific papers
Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2) for the treatment of allergic inflammatory diseases
Kaila, Neelu,Follows, Bruce,Leung, Louis,Thomason, Jennifer,Huang, Adrian,Moretto, Alessandro,Janz, Kristin,Lowe, Michael,Mansour, Tarek S.,Hubeau, Cedric,Page, Karen,Morgan, Paul,Fish, Susan,Xu, Xin,Williams, Cara,Saiah, Eddine
, p. 1299 - 1322 (2014/03/21)
Previously we reported the discovery of CRA-898 (1), a diazine indole acetic acid containing CRTH2 antagonist. This compound had good in vitro and in vivo potency, low rates of metabolism, moderate permeability, and good oral bioavailability in rodents. H
INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS
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Page/Page column 67; 68, (2011/05/08)
Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.
