1297471-95-4

Upstream product

• 552-16-9 ortho-nitrobenzoic acid 
• 2666-93-5 (S)-Leu-OMe 
• 474089-60-6 methyl (S)-N-(2-nitrobenzoyl)leucinate 

Downstream Products

• 1297471-96-5 methyl (S)-2-[2-[(S)-2-(2-aminobenzamido)-4-methylpentanamido]benzamido]-4-methylpentanoate 
• 1297471-97-6 methyl (S)-4-methyl-2-[2-[(S)-4-methyl-2-[2-[(S)-4-methyl-2-(2-nitrobenzamido)pentanamido]-benzamido]pentanamido]benzamido]pentanoate 
• 1297471-98-7 (S)-2-[2-[(S)-2-[2-[(S)-2-(2-aminobenzamido)-4-methylpentanamido]benzamido]-4-methylpentanamido]benzamido]-4-methylpentanoic acid 
• 1316638-62-6 (S)-2-[2-[(S)-2-(2-aminobenzamido)-4-methylpentanamido]benzamido]-4-methylpentanoic acid 

Relevant academic research and scientific papers

Synthesis and C2-symmetric structure of a cyclotetrapeptide composed of anthranilic acid and leucine

A chiral cyclotetrapeptide (1) was synthesized from 2-nitrobenzoic acid and leucine. A single-crystal X-ray of the compound revealed a C 2-symmetric bowl-shaped structure. The cyclic compound had a unique hydrogen-bonding network composed of three-centered hydrogen bonds and bifurcated hydrogen bonds between NH and CO of anthranilic residue. The NMR spectra and molecular modeling of 1 also suggested the chiral bowl structure.

Synthesis of a chiral C3-symmetric bowl-shaped cyclohexapeptide composed of anthranilic acid and leucine

A chiral C3-syrnmetric bowl-shaped cyclohexapeptide (1), composed of anthranilic acid (2-aminobenzoic acid) and α-amino acid in an alternating sequence, was synthesized from 2-nitrobenzoic acid and leucine. The 1H and 13CNMR spectra of 1 suggest a chiral C 3-symmetric bowl-shaped structure. Molecular mechanic calculation revealed that the cyclohexapeptide becomes a bowl-shaped structure when all three α-amino acid components have homochiral side chains. The Japan Institute of Heterocyclic Chemistry.