1297474-55-5

Basic information

• Product Name: C₁₉H₁₁ClN₂O₂S
• CAS NO: 1297474-55-5
• Molecular Weight: 366.828
• Mol File: 1297474-55-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₁ClN₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₁ClN₂O₂S(1297474-55-5)
• EPA Substance Registry System: C₁₉H₁₁ClN₂O₂S(1297474-55-5)

Safety Data

• Hazardous Substances Data: 1297474-55-5(Hazardous Substances Data)

Upstream product

• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 36716-75-3 4-(p-chlorophenyl)-3-cyclohexen-1-one 
• 14472-80-1 4-(4-chlorophenyl)cyclohexan-1-one 
• 13865-19-5 4-oxobutanoic acid methyl ester 
• 1297474-44-2 C₁₅H₁₁ClN₂OS 
• 1297474-35-1 C₁₅H₁₅ClN₂OS 

Downstream Products

• 1297474-20-4 C₁₉H₁₃ClN₂O₃S 

Relevant articles and documents

Aryl extensions of thienopyrimidinones as fibroblast growth factor receptor 1 kinase inhibitors

Optimization of thienopyrimidinone derivatives as FGFR1 kinase inhibitors is being pursued. The present results confirm predictions of computational modeling that an aryl substituent can be introduced at the 2-position in structure 3. The substituent is anticipated to project deeper into the binding site and provide opportunities for enhanced activity and selectivity. The most potent analog reported herein, 13, has a 4-hydroxyphenyl substituent and yields an IC50 of 6 μM for inhibition of phosphorylation by FGFR1 kinase. It was also found that the western anisole-containing substituent in 3 can be replaced by a propionic acid group with no loss in potency and with potentially significant gains in pharmacologically relevant properties.