14472-80-1

Basic information

• Product Name: Cyclohexanone, 4-(4-chlorophenyl)-
• Synonyms: Cyclohexanone, 4-(4-chlorophenyl)-;4-(4-chlorophenyl)cyclohexanone;4-(p-Chlorophenyl)cyclohexanone
• CAS NO: 14472-80-1
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 14472-80-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 138-141 °C
• Boiling Point: 323.664 °C at 760 mmHg
• Flash Point: 171.767 °C
• Appearance: colorless liquid
• Density: 1.165g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: Cyclohexanone, 4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)
• EPA Substance Registry System: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)

Safety Data

• Hazardous Substances Data: 14472-80-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

4-(4-Chlorophenyl)cyclohexanone (cas# 14472-80-1) is a compound useful in organic synthesis.

InChI:InChI=1/C12H13ClO/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-2,5-6,10H,3-4,7-8H2

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 930766-09-9 4-(4-chlorophenyl)cyclohexan-1-ol 
• 155098-65-0 4-(4-oxocyclohexyl)phenyl trifluoromethanesulfonate 
• 1409956-58-6 2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 106-39-8 bromochlorobenzene 
• 36716-75-3 4-(p-chlorophenyl)-3-cyclohexen-1-one 
• 637-87-6 1-Chloro-4-iodobenzene 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 126991-60-4 4-(4-chlorophenyl)cyclohex-3-enone monoehtylene ketal 
• 25253-51-4 4-(4-chlorophenyl)cyclohexanone monoehtylene ketal 
• 36716-71-9 4-(4-chlorophenyl)-4-hydroxycyclohexanone 
• 101598-25-8 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester 

Downstream Products

• 98322-65-7 4-(4-Chloro-phenyl)-cyclohexanol 
• 1297474-44-2 C₁₅H₁₁ClN₂OS 
• 1297474-55-5 C₁₉H₁₁ClN₂O₂S 
• 1297474-20-4 C₁₉H₁₃ClN₂O₃S 
• 1297474-35-1 C₁₅H₁₅ClN₂OS 
• 1402080-52-7 5-(4-chlorophenyl)oxepan-2-one 
• 930766-09-9 (1S,4S)-4-(4-chlorophenyl)cyclohexan-1-ol 
• 1421369-93-8 4-(4-chlorophenyl)-1-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)cyclohexyl 2,2,2-trifluoroacetate 
• 1409956-67-7 cis/trans-2-(4-(4-chlorophenyl)cyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 1409956-62-2 2-(4-(4-chlorophenyl)cyclohex-1-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one 

Relevant articles and documents

Desymmetrizing Isomerization of Alkene via Thiazolinyl Iminoquinoline Cobalt Catalysis

We report a cobalt-catalyzed desymmetrizing isomerization of exo-cyclic alkenes to generate chiral 1-methylcyclohexene derivatives with good yields and enantioselectivities. A novel chiral thiazolinyl iminoquinoline ligand and its cobalt complex were desi

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

Method for synthesizing 4-(4-chlorphenyl) cyclohexanone

The invention relates to the filed of organic synthesis, and discloses a method for synthesizing chemical intermediate 4-(4-chlorphenyl) cyclohexanone. The method includes the steps that (1) 4-(4-hydroxy-phenyl) cyclohexanone and pyridine are mixed in an