1297599-20-2

Upstream product

• 1282624-10-5 C₁₉H₁₉F₂NO 
• 79-04-9 chloroacetyl chloride 
• 96-22-0 pentan-3-one 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 1297599-26-8 1-[2-(1H-imidazol-1-yl)acetyl]-3,5-dimethyl-2,6-bis(m-fluoro-phenyl)piperidin-4-one 
• 1297599-28-0 1-[2-(1H-benzotriazol-1-yl)acetyl]-3,5-dimethyl-2,6-bis(m-fluorophenyl)piperidin-4-one 
• 1282624-19-4 1-[2-(4-ethoxycarbonylpiperazin-1-yl)acetyl]-3,5-dimethyl-2,6-bis(m-fluorophenyl)piperidin-4-one 

Relevant academic research and scientific papers

Design and synthesis of novel piperazine unit condensed 2,6-diarylpiperidin-4-one derivatives as antituberculosis and antimicrobial agents

A new series of 1-[2-(4-ethoxycarbonylpiperazine-1-yl)acetyl]-2,6- diarylpiperidin-4-ones (3a-3j) has been synthesized by conventional method and were characterized by IR, elemental analysis, mass spectral, 1H NMR, 13C NMR, and single crystal X-ray diffraction analysis. The synthesized compounds were evaluated for their antituberculosis activity against Mycobacterium tuberculosis H37Rv (ATCC-27294) and also its antimicrobial activity were examined against five familiar bacterial and fungal strains. Among the synthesized compounds, compounds 3e-3j exhibit higher inhibition potency (16 μg/ml) against M. tuberculosis H37Rv. Furthermore, compounds containing fluoro substituent in the phenyl ring at C-2 and C-6 positions of the piperidin-4-one motif (compounds 3c, 3d, and 3i) exerted better antibacterial and antifungal activity than the other phenyl-substituted compounds. Springer Science+Business Media, LLC 2011.