1297610-98-0Relevant academic research and scientific papers
Ligand-free suzuki cross-coupling reactions: Application to β-Halo-α,β-unsaturated aldehydes
Gogoi, Pranjal,Bezboruah, Pranjal,Boruah, Romesh C.
supporting information, p. 5032 - 5035 (2013/11/06)
A facile, efficient, ligand-free Suzuki-Miyaura reaction of β-halo α,β-unsaturated aldehydes with boronic acids in aqueous media at room temperature is described. Under the optimized conditions, both steroidal and nonsteroidal β-halo α,β-unsaturated aldehydes reacted rapidly with the boronic acids to provide a series of aryl-substituted derivatives in excellent yields. Moreover, the protocol was extended to the direct one-pot synthesis of polycyclic aromatic hydrocarbons through a Suzuki-Miyaura cross-coupling/aldol condensation cascade reaction under microwave irradiation. An efficient ligand-free Suzuki-Miyaura reaction is reported. A range of boronic acids varying in their electronic character were efficiently coupled to β-halo α,β-unsaturated aldehydes. This protocol was extended to the direct one-pot synthesis of polycyclic aromatic hydrocarbons through a Suzuki-Miyaura cross-coupling/aldol condensation cascade reaction under microwave irradiation. Copyright
Palladium-catalyzed novel arylations of cyclic β-bromo α,β-unsaturated aldehydes with triarylbismuths as multicoupling organometallic nucleo-philes
Rao, Maddali L. N.,Banerjee, Debasis,Dhanorkar, Ritesh J.
supporting information; experimental part, p. 273 - 279 (2011/04/16)
Cross-coupling arylations of cyclic β-bromo α,β -unsaturated aldehydes were carried out with triarylbismuths as atom-efficient multicoupling organometallic reagents under palladium-catalyzed conditions. These reactions afforded the corresponding arylated alkenes in an efficient manner with good to high yields. Georg Thieme Verlag Stuttgart.
