129762-57-8Relevant academic research and scientific papers
REACTIONS OF POLYFLUOROCARBONYL COMPOUNDS WITH 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE AND ITS DERIVATIVES
Sviridov, V. D.,Chkanikov, N. D.,Galakhov, M. V.,Shklyaev, Yu. V.,Shklyaev, V. S.,et al.
, p. 1268 - 1272 (1990)
1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C-hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C1-CH3 group at 20 deg C.The products with the ketoesters are converted upon heating to γ-lactams.Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C1-CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20 deg C to give exclusively γ-lactams and do not give reaction products with hexafluoroacetone.
