REACTIONS OF POLYFLUOROCARBONYL COMPOUNDS WITH 1,3,3-TRIMETHYL-3,4-DIHYDROISOQUINOLINE AND ITS DERIVATIVES

Article abstract of DOI:10.1007/BF00962396

1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C-hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C¹-CH3 group at 20 deg C.The products with the ketoesters are converted upon heating to γ-lactams.Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C¹-CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20 deg C to give exclusively γ-lactams and do not give reaction products with hexafluoroacetone.