Bulletin of the Academy of Sciences of the USSR Division of Chemical Science p. 1268 - 1272 (1990)
Update date:2022-08-02
Topics:
Sviridov, V. D.
Chkanikov, N. D.
Galakhov, M. V.
Shklyaev, Yu. V.
Shklyaev, V. S.
et al.
1,3,3-Trimethyl-3,4-dihydroisoquinolines, which exist in the imine form, undergo C-hydroxyalkylation upon reaction with hexafluoroacetone and esters of trifluoropyruvic acid at the C1-CH3 group at 20 deg C.The products with the ketoesters are converted upon heating to γ-lactams.Derivatives of 1,3,3-trimethyl-3,4-dihydroisoquinoline substituted at C1-CH3 group and existing in the enamine form, react with esters of trifluoropyruvic acid at 20 deg C to give exclusively γ-lactams and do not give reaction products with hexafluoroacetone.
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