1297931-02-2

Upstream product

• 1297931-00-0 2-chloro-4-(4-methoxyphenoxy)-5-nitropyrimidine 
• 1297930-95-0 {2-[2,4-Bis-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]ethyl}-carbamic acid tert-butyl ester 
• 1297931-01-1 2-Chloro-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamine 
• 69610-41-9 Boc-L-Pro-H 
• 1297930-97-2 N₁-[2,4-Bis-(4-methoxy-phenoxy)-pyrimidin-5-yl]ethane-1,2-diamine 
• 4023-02-3 1H-pyrazole-1-carboximidamide hydrochloride 
• 76-05-1 trifluoroacetic acid 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 1297931-04-4 2-(S)-{[2-(4-methoxybenzenesulfinyl)-4-(4-methoxyphenoxy)-pyrimidin-5-ylamino]-methyl}pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1297931-18-0 2-(S)-{[2-(3-fluoro-phenylamino)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1297931-16-8 2-(S)-{[2-(3-fluoro-phenoxy)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1297931-13-5 2-(S)-{[4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1297931-11-3 2-(S)-({4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-ylamino}-methyl)pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1297930-10-9 {4-(4-methoxyphenoxy)-2-[2-(4-methoxyphenyl)vinyl]-pyrimidin-5-yl}-pyrrolidin-2-(S)-ylmethylamine 
• 1297929-77-1 [4-(4-methoxy-phenoxy)-2-phenylethynyl-pyrimidin-5-yl]-pyrrolidin-2-(S)-ylmethyl-amine hydrochloride 
• 1298100-81-8 2-(S)-{[2-cyano-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1298100-89-6 2-(S)-{[4-(4-methoxy-phenoxy)-2'-methylsulfanyl-[2,4]bipyrimidin-yl-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1298100-73-8 2-(S)-{[4-(4-methoxy-phenoxy)-2-(5-methylsulfanyl-pyridin-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1298100-83-0 2-(S)-{[2-(N-hydroxycarbamimidoyl)-4-(4-methoxy-phenoxy)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1298100-86-3 2-(S)-{[4-(4-methoxy-phenoxy)-2-(5-oxo-4,5-dihydro-[1,2,4]oxadiazol-3-yl)-pyrimidin-5-ylamino]-methyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, Y, R2, R3, and Ra are defined herein.

PYRIMIDINE COMPOUNDS AS DELTA OPIOID RECEPTOR MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:wherein R1, R2, R3, and L, A, and Ra are defined herein.