1298015-31-2

Upstream product

• 25260-60-0 cis-1,4-bis(acetyloxy)but-2-ene 
• 1298015-30-1 (4R,6S)-4-((S)-but-3-en-2-yl)-2-methoxy-6-(2-((4-methoxybenzyl)oxy)ethyl)-1,3,2-dioxaphosphinane 2-oxide 

Downstream Products

• 1298015-32-3 (4S,6R)-2-methoxy-4-(2-((4-methoxybenzyl)oxy)ethyl)-6-((S)-pent-4-en-2-yl)-1,3,2-dioxaphosphinane 2-oxide 
• 1298015-27-6 (3S,5R,6S)-1-((4-methoxybenzyl)oxy)-6-methylnon-8-ene-3,5-diol 
• 1298015-33-4 (4S,5R,7S)-9-((4-methoxybenzyl)oxy)-4-methyl-7-((triisopropylsilyl)oxy)non-1-en-5-ol 
• 1298015-34-5 (5R,7S)-9,9-diisopropyl-7-(2-((4-methoxybenzyl)oxy)ethyl)-10-methyl-5-((S)-pent-4-en-2-yl)-2,4,8-trioxa-9-silaundecane 
• 1298015-35-6 (3S,5R,6S)-1-((4-methoxybenzyl)oxy)-5-(methoxymethoxy)-6-methylnon-8-en-3-ol 
• 1298015-38-9 (4S,5R,7S)-7-hydroxy-9-((4-methoxybenzyl)oxy)-4-methylnon-1-en-5-yl 2-allyl-6-hydroxybenzoate 

Relevant academic research and scientific papers

Phosphate tether-mediated approach to the formal total synthesis of (-)-salicylihalamides A and B

A concise formal synthesis of the cytotoxic macrolides (-)- salicylihalamides A and B is reported. Key features of the synthetic strategy include a chemoselective hydroboration, highly regio- and diastereoselective methyl cuprate addition, Pd-catalyzed formate reduction, and an E-selective ring-closing metathesis to construct the 12-membered macrocycle subunit. Overall, two routes have been developed from a readily prepared bicyclic phosphate (4 steps), a 13-step route and a more efficient 9-step sequence relying on regioselective esterification of a key diol.