1298015-60-7

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 57944-13-5 3'-fluoro-3'-desoxyuridine 

Downstream Products

• 1298015-64-1 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-2'-cyanoethylphosphoramidite-β-D-xylofuranosyl)uracil 
• 1298015-63-0 5'-O-(4,4-dimethoxy)trityl-3-deoxy-3-ribofluoro-2-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)uridine 

Relevant academic research and scientific papers

Synthesis and structural studies of S-type/N-type-locked/frozen nucleoside analogues and their incorporation in RNA-selective, nuclease resistant 2′-5′ linked oligonucleotides

2′-endo locked or frozen (S-type)/3′-endo locked or frozen (N-type) nucleoside analogues were synthesized. Conformational analysis based on 3JHH and NOE measurements is presented which is further confirmed by X-ray crystal structural

COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF DISEASE

Disclosed are compounds and compositions for the activation or induction of expression of a pattern recognition receptor (e.g., STING, RIG-I, MDA5), and methods of use thereof.

Probing the furanose conformation in the 2′-5′strand of isoDNA:RNA duplexes by freezing the nucleoside conformations

Sugar conformations in the isoDNA strand of isoDNA:RNA duplexes are preferred S-type locked/frozen in contrast to N-type locked conformations preferred in DNA:RNA duplexes. The Royal Society of Chemistry.