1298015-61-8

Basic information

• Product Name: 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-β-D-xylofuranosyl)uracil
• Synonyms: 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-β-D-xylofuranosyl)uracil
• CAS NO: 1298015-61-8
• Molecular Weight: 548.568
• Mol File: 1298015-61-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-β-D-xylofuranosyl)uracil(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-β-D-xylofuranosyl)uracil(1298015-61-8)
• EPA Substance Registry System: 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-β-D-xylofuranosyl)uracil(1298015-61-8)

Safety Data

• Hazardous Substances Data: 1298015-61-8(Hazardous Substances Data)

Upstream product

• 18530-84-2 3-deoxy-3-fluoro-1,2-O-isopropylidene-α-D-xylofuranose 
• 70722-99-5 (3aR,5R,6S,6aS)-6-fluoro-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carbaldehyde 
• 18530-81-9 1-((3aR,5R,6S,6aS)-6-Fluoro-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethane-1,2-diol 
• 620630-82-2 1,2 5,6-O-di(isopropylidene)-α-D-allofuranose 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 129885-95-6 1-(3-deoxy-3-fluoro-β-D-xylofuranosyl)uracil 

Downstream Products

• 1298015-64-1 1-(5'-O-dimethoxytrityl-3'-deoxy-3'-fluoro-2'-cyanoethylphosphoramidite-β-D-xylofuranosyl)uracil 

Relevant articles and documents

Probing the furanose conformation in the 2′-5′strand of isoDNA:RNA duplexes by freezing the nucleoside conformations

Sugar conformations in the isoDNA strand of isoDNA:RNA duplexes are preferred S-type locked/frozen in contrast to N-type locked conformations preferred in DNA:RNA duplexes. The Royal Society of Chemistry.

Synthesis and structural studies of S-type/N-type-locked/frozen nucleoside analogues and their incorporation in RNA-selective, nuclease resistant 2′-5′ linked oligonucleotides

2′-endo locked or frozen (S-type)/3′-endo locked or frozen (N-type) nucleoside analogues were synthesized. Conformational analysis based on 3JHH and NOE measurements is presented which is further confirmed by X-ray crystal structural