1298069-17-6

Basic information

• Product Name: 5-chloro-2-(4-fluorophenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole
• CAS NO: 1298069-17-6
• Molecular Weight: 426.049
• Mol File: 1298069-17-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(4-fluorophenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(4-fluorophenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole(1298069-17-6)
• EPA Substance Registry System: 5-chloro-2-(4-fluorophenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole(1298069-17-6)

Safety Data

• Hazardous Substances Data: 1298069-17-6(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 1298069-11-0 4-chloro-2-((4-fluorophenyl)ethynyl)aniline 
• 63069-48-7 p-chloro-o-iodoaniline 
• 76609-16-0 5-chloro-2-(4-fluorophenyl)-1H-indole 
• 181934-30-5 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one 

Relevant articles and documents

One-pot gold-catalyzed synthesis of 3-silylethynyl indoles from unprotected o-alkynylanilines

The Au(III)-catalyzed cyclization of 2-alkynylanilines was combined in a one-pot procedure with the Au(I)-catalyzed C3-selective direct alkynylation of indoles using the benziodoxolone reagent TIPS-EBX to give a mild, easy and straightforward entry to 2-substituted-3-alkynylindoles. The reaction can be applied to unprotected anilines, was tolerant to functional groups and easy to carry out (RT, and requires neither an inert atmosphere nor special solvents).