1298086-15-3

Basic information

• Product Name: 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene
• Synonyms: 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene;EOS-60362
• CAS NO: 1298086-15-3
• Molecular Formula: C₂₂H₂₀BrClO₂
• Molecular Weight: 431.75
• Mol File: 1298086-15-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 495.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.341±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene(1298086-15-3)
• EPA Substance Registry System: 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene(1298086-15-3)

Safety Data

• Hazardous Substances Data: 1298086-15-3(Hazardous Substances Data)

Usage

General Description

The chemical compound 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene is a complex organic compound with a long molecular structure. It contains benzyl, ethoxyphenyl, bromo, and chloro groups attached to a central benzene ring. The compound is likely to have a wide range of chemical properties and potential applications due to the presence of multiple functional groups and the diverse nature of its structure. Its synthesis or use may involve a series of reactions and processes to achieve the desired molecular arrangement and properties. Due to its complexity and potentially diverse reactivity, this compound may be of interest to researchers in the field of organic chemistry and materials science.

Upstream product

• 41842-30-2 4-ethoxyphenylmagnesium bromide 
• 189628-37-3 2-chloro-5-bromobenzaldehyde 
• 1280647-32-6 (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol 
• 100-51-6 benzyl alcohol 
• 461432-22-4 (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone 
• 100-39-0 benzyl bromide 

Downstream Products

• 461432-25-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 461432-26-8 dapagliflozin 
• 1079083-63-8 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 915095-99-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate 
• 1417573-74-0 1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucopyranoside 

Relevant articles and documents

Preparation methods of SGLT-2 diabetes inhibitors and intermediates thereof

The invention provides a preparation method of an intermediate compound 7 of an SGLT-2 diabetes inhibitor dapagliflozin and an intermediate compound 8 of a SGLT-2 diabetes inhibitor empagliflozin, and new synthesis method of two final products. The preparation method comprises the following steps: carrying out carbonyl group reduction and hydroxyl group protection on a (5-halo-2-chlorophenyl)(4-ethoxyphenyl)ketone compound 1 used as an initial raw material to obtain a Grignard addition reaction key compound 4, and carrying out Grignard addition and acetylation to obtain the compound 7 and the compound 8. The dapagliflozin and the empagliflozin are respectively prepared from the compound 8. The methods have the advantages of simplicity in operation, high yield, high purity of the obtained products, and suitableness for amplified production.

DIOXA-BICYCLO[3.2.1]OCTANE-2,3,4-TRIOL DERIVATIVES

Compounds of Formula (A) and (B) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by sodium-glucose transporter inhibitors (in particular, SGLT2 inhibitors).