129820-44-6

Basic information

• Product Name: 2-(azidomethyl)thiophene
• Synonyms: 2-(azidomethyl)thiophene
• CAS NO: 129820-44-6
• Molecular Weight: 139.181
• Mol File: 129820-44-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(azidomethyl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(azidomethyl)thiophene(129820-44-6)
• EPA Substance Registry System: 2-(azidomethyl)thiophene(129820-44-6)

Safety Data

• Hazardous Substances Data: 129820-44-6(Hazardous Substances Data)

Upstream product

• 45438-73-1 2-thenyl bromide 

Downstream Products

• 27757-85-3 2-Aminomethylthiophene 
• 7404-67-3 2-<(methylamino)methyl>thiophene hydrochloride 
• 547698-18-0 N-((thiophen-2-yl)methyl)cyclohexanecarboxamide 
• 1429503-91-2 tert-butyl {(S)-1-[(S)-2-cyanopyrrolidin-1-yl]-1-oxo-3-[4-(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)phenyl]propan-2-yl}carbamate 
• 98-03-3 thiophene-2-carbaldehyde 
• 1356147-06-2 phenyl(1-(thiophen-2-ylmethyl)-1H-1,2,3-triazol-4-yl)methanone 
• 114261-50-6 2-thienyl-N,N-bis[(E)-2-thienylmethylidene]methanediamine 

Relevant articles and documents

Interrupted CuAAC-Thiolation for the Construction of 1,2,3-Triazole-Fused Eight-Membered Heterocycles from O-/N-Propargyl derived Benzyl Thiosulfonates with Organic Azides

A copper(I)-catalyzed interrupted click-sulfenylation of O-/N-propargyl benzyl thiosulfonates with organic azides has been disclosed. The unified CuAAC-thiolation provides a wide range of triazole-fused eight-membered heterocycles in good to high (51–94%) yields under mild reaction conditions. Moreover, a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates, benzyl bromide, and sodium azide to deliver fused-triazoles in 61–74% yields. From a synthetic point of view, the present protocol has been demonstrated at gram-scale reactions. A plausible mechanism is also proposed based on experimental results and control experiments. (Figure presented.).