129822-42-0

Basic information

• Product Name: (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER
• Synonyms: (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER;2-METHYL-4-METHOXYANILINE TERT-BUTYL CARBAMATE;tert-Butyl 4-methoxy-2-methylphenylcarbamate
• CAS NO: 129822-42-0
• Molecular Formula: C₁₃H₁₉NO₃
• Molecular Weight: 237.3
• Mol File: 129822-42-0.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(129822-42-0)
• EPA Substance Registry System: (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER(129822-42-0)

Safety Data

• Hazardous Substances Data: 129822-42-0(Hazardous Substances Data)

Usage

General Description

(4-Methoxy-2-methyl-phenyl)-carbamic acid tert-butyl ester is a chemical compound with the molecular formula C13H19NO4. It is commonly used as a building block for the synthesis of various pharmaceuticals and agricultural chemicals. (4-METHOXY-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER is known for its potential applications as an intermediate in the production of drugs and agrochemicals, as well as in the development of other organic compounds. It is a crystalline solid with a white to light yellow appearance, and it is commonly handled and stored in a dry, cool and well-ventilated area. Overall, the compound has a wide range of potential uses in the field of pharmaceuticals and chemical synthesis.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 102-50-1 2-methyl-4-methoxyaniline 

Downstream Products

• 138344-12-4 (2-tert-Butoxycarbonylamino-5-methoxy-phenyl)-acetic acid 
• 260391-79-5 N-(tert-butoxycarbonyl)-2-methyl-p-benzoquinone imine dimethyl acetal 
• 163688-09-3 1-[2-(tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone 
• 138344-01-1 [4-Methoxy-2-(2-oxo-hexyl)-phenyl]-carbamic acid tert-butyl ester 
• 1572438-32-4 C₁₈H₂₇NO₄ 
• 1572438-43-7 C₁₇H₂₅NO₄ 
• 86735-53-7 2-methyl-4-methoxy-N-methylaniline 
• 57197-11-2 4,4-dimethoxy-2-methylcyclohexane-2,5-dien-1-one 
• 1263299-69-9 tert-butyl [2-(2-cyclopentyl-2-hydroxyethyl)-4-methoxyphenyl]carbamate 
• 1263299-66-6 tert-butyl [4-methoxy-2-(2-hydroxy-3,3-dimethylbutyl)phenyl]carbamate 
• 1263299-70-2 Methyl 3-{[2-(2-Cyclopentyl-2-hydroxyethyl)-4-methoxyphenylamino]methyl}benzoate 
• 1263297-51-3 Methyl 3-(2-tert-butyl-5-methoxyindol-1-ylmethyl)benzoate 
• 1263299-68-8 methyl 3-{[2-(2-hydroxy-3,3-dimethylbutyl)-4-methoxyphenylamino]methyl}benzoate 
• 1263299-67-7 1-(2-amino-5-methoxyphenyl)-3,3-dimethylbutan-2-ol 

Relevant articles and documents

Metal-free synthesis of fluorinated indoles enabled by oxidative dearomatization

Nitrogen heterocycles are found in a majority of approved small-molecule pharmaceuticals, and the number of approved fluorinated drugs is increasing each decade. Therefore, new approaches for accessing fluorinated nitrogen heterocycles are of great significance. A novel, scalable, and metal-free method for accessing a wide range of fluorinated indoles is described. This oxidative-dearomatization-enabled approach assembles 2-trifluoromethyl NH-indole products from simple commercially available anilines with hexafluoroacetylacetone in the presence of an organic oxidant. The nature of the aniline N-capping group is critical for the success of this new reaction. Furthermore, the indole products contain a 3-trifluoroacetyl group, which can be exploited to access a plethora of useful functional groups.

Facile synthesis and antitumor activity of novel N(9) methylated AHMA analogs

A facile synthesis of novel antitumor N(9)-methyl-3-(9-acridinylamino)-5- hydroxymethylaniline (AHMA) derivatives is described. Boc protection of aminobenzoic acids followed by LiAlH4 reduction yielded novel methylaminobenzyl alcohol reactants. Their interaction with 9-chloroacridine provides N(9)-methylated AHMA derivatives for biological screening. A preliminary anti-proliferative assay against seven cancer cell lines identified compounds with low μM IC50 values. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT 6 receptor agonists

A series of 2-alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)- 1H-indole with an ICsub