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Downstream Products

• 212895-31-3 Acetic acid (2R,3S,4S,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-3-phenylselanyl-tetrahydro-pyran-2-yl ester 
• 212895-03-9 Acetic acid (2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-3-phenylselanyl-tetrahydro-pyran-2-yl ester 
• 222189-65-3 Toluene-4-sulfonic acid (2R,3S,4R)-4-benzyloxy-3-[(2S,3R,4S,5R,6R)-4,5-bis-(tert-butyl-dimethyl-silanyloxy)-3-iodo-6-methyl-tetrahydro-pyran-2-yloxy]-3,4-dihydro-2H-pyran-2-ylmethyl ester 
• 212895-32-4 (1S,3R,9R,10S)-9-[(2R,3S,4S,5R,6R)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-methyl-3-phenylselanyl-tetrahydro-pyran-2-yloxy]-3-methyl-4,11-dioxa-bicyclo[8.1.0]undecane-5,7-dione 

Relevant academic research and scientific papers

First glycosylation of decarestrictine B and D: A route to hybrid antibiotics

The naturally occurring ten-membered lactones decarestrictine B (4) and D (5), which lower cholesterol levels, were glycosylated with deoxygenated 2-selenoglycosyl acetates 7a, 7b, and glycal 10 (obtained from D-glucose), and glycal 13 (obtained from L-rhamnose). Depending on the glycosylation method employed, the triol decarestrictine D was glycosylated with a high degree of regioselectivity. A set of hybrid structures were yielded by O-deblocking and in most cases reductive removal of a halogen or a phenylselenyl group from C-2 of the glycosides 14a-f, 20a, 20b, and 24. These hybrids were subjected to preliminary biological tests in which the novel glycoconjugates 15d and 15e displayed DNA-binding properties. The naturally occurring ten-membered lactones decarestrictine B (4) and D (5), which lower cholesterol levels, were glycosylated with deoxygenated 2-seleno-glycosyl acetates 7a, 7b, and glycal 10 (obtained from D-glucose), and glycal 13 (obtained from L-rhamnose). Depending on the glycosylation method employed, the triol decarestrictine D was glycosylated with a high degree of regioselectivity. A set of hybrid structures were yielded by O-deblocking and in most cases reductive removal of a halogen or a phenylselenyl group from C-2 of the glycosides 14a-f, 20a, 20b, and 24. These hybrids were subjected to preliminary biological tests in which the novel glycoconjugates 15d and 15e displayed DNA-binding properties.