129832-33-3

Upstream product

• 822-66-2 3-cyclohexen-1-ol 
• 129801-82-7 (1R,2R,4S)-2,4-Bis-benzyloxy-cyclohexanol 
• 84029-18-5 (1RS,3RS,6SR)-3-(benzyloxy)-7-oxabicyclo[4.1.0]heptane 
• 2461-22-5 (1SR,3SR,6RS)-7-oxabicyclo[4.1.0]heptan-3-ol 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 
• 129801-87-2 [(1R,2R,4S)-2-Benzyloxy-4-(4-methoxy-benzyloxy)-cyclohexyloxy]-tert-butyl-dimethyl-silane 
• 129801-88-3 (3R,4R)-3-Benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexanone 
• 129801-86-1 (1S,3S,6R)-3-(4-Methoxy-benzyloxy)-7-oxa-bicyclo[4.1.0]heptane 
• 138638-39-8 (2R,4S)-2,4-Bis-benzyloxy-cyclohexanone 

Downstream Products

• 129832-35-5 (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane 
• 129801-84-9 Phosphoric acid dibenzyl ester (1R,2R,4R)-2,4-bis-benzyloxy-cyclohexyl ester 
• 129801-85-0 Phosphoric acid mono-((1S,2S,4S)-2,4-dihydroxy-cyclohexyl) ester 
• 129801-85-0 Phosphoric acid mono-((1S,2R,4S)-2,4-dihydroxy-cyclohexyl) ester 
• 129832-36-6 (1R)-phosphoryloxy-(2S,4R)-dihydroxycyclohexane 
• 129832-34-4 (1R,2S,4R)-2,4-Bis-benzyloxy-cyclohexanol 
• 129801-82-7 (1S,2R,4S)-2,4-Bis-benzyloxy-cyclohexanol 
• 138638-37-6 [((1R,2S,4R)-2,4-Bis-benzyloxy-cyclohexyloxy)-(diethoxy-phosphoryl)-methyl]-phosphonic acid diethyl ester 
• 138638-43-4 [((1R,2S,4R)-2,4-Dihydroxy-cyclohexyloxy)-phosphono-methyl]-phosphonic acid 
• 138638-38-7 [1-((1R,2S,4R)-2,4-Dihydroxy-cyclohexyloxy)-1-phosphono-ethyl]-phosphonic acid 
• 138638-36-5 ((1R,2S,4R)-2,4-Bis-benzyloxy-cyclohexyloxymethyl)-phosphonic acid diethyl ester 
• 138638-37-6 [((1S,2R,4S)-2,4-Bis-benzyloxy-cyclohexyloxy)-(diethoxy-phosphoryl)-methyl]-phosphonic acid diethyl ester 
• 138638-43-4 [((1S,2R,4S)-2,4-Dihydroxy-cyclohexyloxy)-phosphono-methyl]-phosphonic acid 
• 138638-36-5 ((1S,2R,4S)-2,4-Bis-benzyloxy-cyclohexyloxymethyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Mechanism and inhibition of inositol monophosphatase

The design and synthesis of inhibitors of inositol monophosphatase (IMPase, B.C. 3.1.3.25) based on natural substrates and lead compounds discovered by screening is discussed. The physiologically relevant form of the enzyme and a likely mechanism have been deduced from structure-activity relationships, site-directed mutagenesis experiments, X-ray crystallography and molecular modelling.

Identification of (1S)-Phosphoryloxy-(2R,4S)-dihydroxycyclohexane as a Potent Inhibitor of Inositol Monophosphatase

The 3,5,6-trisdeoxy derivative of myo-inositol 1-monophosphate, (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane , derived from the parent substrate by a strategy of hydroxy deletion, has been synthesised and shown to be the most potent inhibitor of inositol monophosphatase yet identified.