129833-44-9

Basic information

• Product Name: 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid
• Synonyms: 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid
• CAS NO: 129833-44-9
• Molecular Weight: 304.275
• Mol File: 129833-44-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid(129833-44-9)
• EPA Substance Registry System: 2-(2-Carboxymethyl-phenoxy)-4-fluoro-3-methyl-benzoic acid(129833-44-9)

Safety Data

• Hazardous Substances Data: 129833-44-9(Hazardous Substances Data)

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 57817-03-5 6-fluoro-7-methylindoline-2,3-dione 
• 117571-22-9 (2-hydroxyphenyl)acetic acid disodium salt 
• 129833-35-8 4-fluoro-2-iodo-3-methylbenzoic acid 

Relevant articles and documents

Potential Antitumor Agents. 61. Structure-Activity Relationships for in Vivo Colon 38 Activity among Disubstituted 9-Oxo-9H-xanthene-4-acetic Acids

Analogues of 9-oxo-9H-xanthene-4-acetic acid (XAA) bearing small, lipophilic 5-substituents are among the most dose-potent compounds yet reported with the capability of causing hemorrhagic necrosis of implanted colon 38 tumors in mice.To further extend structure-activity relationships among this class of compound, a series of XAA derivatives bearing two small lipophilic groups at various positions have been prepared and evaluated.The 5,6-disubstituted compounds in particular show consistently high levels of both dose potency and activity, suggesting this is the optimal configuration among substituted 9-oxo-9H-xanthene-4-acetic acids.The 5,6-dimethyl and 5-methyl-6-methoxy are the most effective analogues, showing in vivo colon 38 activity comparable to that of FAA at 10-15-fold lower doses and superior activity to FAA at the respective optimal doses, and the former has been selected for detailed evaluation.