129865-57-2

Upstream product

• 70-11-1 α-bromoacetophenone 
• 129865-59-4 (2-chloro-1,3-thiazol-5-yl)(phenyl)methanone 
• 109-89-7 diethylamine 

Relevant academic research and scientific papers

Facile synthesis of 5-acyl-2-amino-1,3-thiazole by the reaction of thiaazadienes with α-halo ketones

The reaction of thiaazadienes (1a-e) with α-halo ketones (2a-d) gives 5-acyl-2-amino-1,3-thiazole (3a-q) in high yields.

An Easy General Synthesis of 2-(N,N-Dialkylamino)thiazol-5-yl Aldehydes and Ketones

Reaction between 2-chloro-5-thiazolyl-lithium and N,N-dialkylformamides or amides gave 2-N,N-dialkylaminothiazol-5-yl aldehydes or ketones on quenching with water.Quenching with acid gave 2-chlorothiazole-5-yl aldehydes or ketones, from which chloride was easily displaced by free amines.