129872-82-8 Usage
Uses
Used in Pharmaceutical Industry:
2,4-dichloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine is used as a drug candidate for the development of anticancer agents due to its capacity to disrupt the growth of cancer cells by inhibiting the DHODH enzyme, thereby hindering DNA and RNA synthesis essential for their proliferation.
Used in Antiviral Applications:
In the field of antiviral drug development, 2,4-dichloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine is utilized as a potential antiviral agent, leveraging its inhibitory effect on DHODH to impede the replication of certain viruses, which rely on this enzyme for their life cycle.
Used in Autoimmune and Inflammatory Disease Treatment:
2,4-dichloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine is employed as a therapeutic agent for autoimmune and inflammatory diseases, with preclinical studies indicating its potential to modulate immune responses and alleviate disease symptoms.
Further research and clinical trials are essential to fully explore and understand the therapeutic applications of 2,4-dichloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine, ensuring its safe and effective use in medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 129872-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,9,8,7 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 129872-82:
(8*1)+(7*2)+(6*9)+(5*8)+(4*7)+(3*2)+(2*8)+(1*2)=168
168 % 10 = 8
So 129872-82-8 is a valid CAS Registry Number.
129872-82-8Relevant academic research and scientific papers
Pyrrolo pyrimidine derivate and application thereof
-
Paragraph 0037-0039; 0057-0059, (2017/11/18)
The invention belongs to the field of medicinal chemistry, and specifically relates to a pyrrolo pyrimidine derivate. The structure of the pyrrolo pyrimidine derivate is shown as formula (I), wherein X and Y independently represent N, O and S or SO; R1 is
Direct C-Glycosylation of Guanine Analogues: The Synthesis and Antiviral Activity of Certain 7- and 9-Deazaguanine C-Nucleosides
Girgis, Nabih S.,Michael, Maged A.,Smee, Donald F.,Alaghamandan, Hassan A.,Robins, Roland K.,Cottam, Howard B.
, p. 2750 - 2755 (2007/10/02)
C-Glycosylation of two guanine analogues, 9-deaza- and 7-deazaguanine, has been achieved under Friedel-Crafts conditions, providing a direct synthetic route to 9-deazaguanosine (4; 2-amino-7-β-D-ribofuranosyl-5H-pyrrolopyrimidin-4(3H)-one) and 8-β-
