129880-21-3Relevant academic research and scientific papers
An activity-based fluorescent probe and its application for differentiating alkaline phosphatase activity in different cell lines
He, Yong,Yu, Junli,Hu, Xiangzi,Huang, Shumei,Cai, Lili,Yang, Liu,Zhang, Huatang,Jiang, Yin,Jia, Yongguang,Sun, Hongyan
, p. 13323 - 13326 (2020)
Herein, a new fluorescent probe, AE-Phos, is reported for detecting the ALP activity with the combined advantages of aggregation-induced emission (AIE) and excited state intramolecular proton transfer (ESIPT). Further detailed fluorescence experiments demonstrated that AE-Phos exhibited excellent selectivity and sensitivity, a large Stokes shift, and a fast response towards ALP. Furthermore, AE-Phos was applied to imaging the ALP activity in different cell lines quantitatively. This journal is
Synthesis and Opto-electronic Properties of BODIPY o-OPhos Systems
Anitha, Thipanni,Mrinalini, Madoori,Vani, Damera,Prasanthkumar, Seelam,Rajender Reddy, Kallu,Giribabu, Lingamallu
, p. 1182 - 1190 (2020/07/30)
Herein, we report the versatile synthetic strategy and opto-electronic properties for the phosphorylation of BODIPY derivatives 5aa-5ak by substituting with an electron-donating/withdrawing group at the ortho position. Nevertheless, this new methodology relatively promotes the tolerance of the aldehyde moiety and the high yield for the synthesis of BODIPY o-OPhos derivatives. The photophysical studies suggest improved optical properties due to the inductive effect of various electron-donating/withdrawing groups. The UV-visible and the emission data suggest that BODIPY o-OPhos derivatives emphasize the property of the excited states with an increase in fluorescence intensity and high quantum yields due to the presence of bulky phospsho-triester at the meso- position which hinders the free rotation around the C-Ar bond and facilitates the development of OLEDs and various organophosphorus warfare agents. Electrochemical studies reveal 5ak depicts the ease of redox activity amongst the 5aa-5ak derivatives. The density functional theory indicates the highest occupied molecular orbital on the BODIPY moiety whereas the lowest unoccupied molecular orbital delocalized on BODIPY and the phospho-triester moieties. Thus, the unique development of the novel BODIPY derivatives with improved optical and redox properties pave the way for fluorescent probes and bioimaging techniques.
Construction of an alkaline phosphatase-specific two-photon probe and its imaging application in living cells and tissues
Zhang, Huatang,Xiao, Peng,Wong, Yin Ting,Shen, Wei,Chhabra, Mohit,Peltier, Raoul,Jiang, Yin,He, Yonghe,He, Jun,Tan, Yi,Xie, Yusheng,Ho, Derek,Lam, Yun-Wah,Sun, Jinpeng,Sun, Hongyan
, p. 220 - 229 (2017/06/29)
Alkaline phosphatase (ALP) is a family of enzymes involved in the regulation of important biological processes such as cell differentiation and bone mineralization. Monitoring the activity of ALP in serum can help diagnose a variety of diseases including bone and liver diseases. There has been growing interest in developing new chemical tools for monitoring ALP activity in living systems. Such tools will help further delineate the roles of ALP in biological and pathological processes. Previously reported fluorescent probes has a number of disadvantages that limit their application, such as poor selectivity and short-wavelength excitation. In this work, we report a new two-photon fluorescent probe (TP-Phos) to selectively detect ALP activity. The probe is composed of a two-photon fluorophore, a phosphate recognition moiety, and a self-cleavable adaptor. It offers a number of advantages over previously reported probes, such as fast reaction kinetics, high sensitivity and low cytotoxicity. Experimental results also showed that TP-Phos displayed improved selectivity over DIFMUP, a commonly utilized ALP probe. The selectivity is attributed to the utilization of an ortho-functionalised phenyl phosphate group, which increases the steric hindrance of the probe and the active site of phosphatases. Moreover, the two-photon nature of the probe confers enhanced imaging properties such as increased penetration depth and lower tissue autofluorescence. TP-Phos was successfully used to image the endogenous ALP activity of hippocampus, kidney and liver tissues from rat.
2-(2-Hydroxyphenyl)imidazolidines and their O-phosphorylated derivatives
Pudovik,Terent’eva,Dobrynin,Bagautdinova, R. Kh.,Kibardina,Pudovik,Burilov
, p. 60 - 65 (2017/07/07)
2-(2-Hydroxyaryl)imidazolidines were synthesized by reaction of aromatic carbonyl compounds with N,N′-dialkylethylenediamines. The title compounds were also prepared using the corresponding Schiff bases instead of carbonyl compounds. Phosphorylation of 2-
WATER-SOLUBLE SHPS AS NOVEL ALKYLATING AGENTS
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Page 9, (2010/02/09)
The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R′ is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OPOsub
α-aminophosphonates bearing free hydroxyl groups in the aromatic rings. Synthesis and NMR characterization
Failla, Salvatore,Finocchiaro, Paolo,Haegele, Gerhard,Kalchenko, Vitaly I.
, p. 63 - 77 (2007/10/03)
In this paper we describe a useful synthetic procedure leading in very good yields to mono- and bis-α-aminophosphonic acid dialkylesters containing the free phenolic hydroxyl group in a strategic position of the aromatic ring in order to enhance complexat
