129880-59-7

Upstream product

• 62-53-3 aniline 
• 5958-44-1 diphenylphosphinomethanol 
• 50-00-0 formaldehyd 
• 829-85-6 diphenylphosphane 
• 1401420-41-4 N,N-bis(diphenylphosphinoylmethyl)aniline 
• 4559-70-0 Diphenylphosphine oxide 

Downstream Products

• 449145-17-9 ReBr(CO)3(((C₆H₅)2PCH₂)2NC₆H₅) 
• 1122502-54-8 PhN(CH₂PPh₂)₂NiCl₂ 
• 1201830-12-7 [{Fe₂(μ-1,3-propanedithiolate)(CO)₅}₂(μ, κ¹, κ¹-Ph₂PCH₂N(Ph)CH₂PPh₂)] 
• 1250872-02-6 Mn(Ph₂PCH₂N(Ph)CH₂PPh₂)(CO)3(Br) 
• 1316861-41-2 [Cu(2,9-dimethyl-1,10-phenanthroline)(N,N-bis((diphenylphosphino)methyl)benzenamine)][B(fluoride)4] 
• 1316861-32-1 [Cu(1,10-phenanthroline)(N,N-bis((diphenylphosphino)methyl)benzenamine)][B(fluoride)4] 
• 1333203-68-1 [(N,N-bis((diphenylphosphino)methyl)phenylamine)CoI₂] 
• 1333203-69-2 [(N,N-bis((diphenylphosphino)methyl)phenylamine)NiI]I 
• 1401420-45-8 cis-[bis(diphenylphosphinomethyl)aniline]dichloroplatinum(II) 

Relevant academic research and scientific papers

New functionalised ditertiary phosphines via phosphorus based Mannich condensation reactions

The one-step synthesis of a family of functionalised ditertiary aminophosphines are described including the X-ray crystal structure of 4-{(Ph2PCH2)2N}C6H4CO 2H.

Highly active cobalt complex catalysts used for alkene hydrosilylation

A series of nitrogen phosphine ligands were synthesized, and the hydrosilylation reaction of alkenes catalyzed using MCl2 in the presence of these ligands was investigated. FeCl2/1(N1, N1, N2, N2-Tetrakis[(diphenylphosphino)methyl]ethane-1,2-diamine) showed low catalytic activity. MnCl2/1, CrCl3/1 and NiCl2/1 showed some catalytic activity. The CoCl2/N,P-ligand catalyst system showed high activity as well as excellent selectivity (The selectivity of the β-adduct was ~100%.) in the hydrosilylation reaction. CoCl2/1 showed the highest catalytic activity (~ >99.9% conversion of 1-octene). Additionally, no α-adduct, dehydrogenative silylation product and octane were detected.

Catalyst Pendent-Base Effects on Cyclization of Alkynyl Amines

A family of [CpRu(PP)(MeCN)]PF6 complexes (2 a–e and 4) were prepared in which the bis-phosphine ligand contains a pendent tertiary amine in the second-coordination sphere. 2 a–e contain PPh2NR′2 ligands with two amine groups as the pendent base. Complex 4 has the PPh2NPh1 ligand with only one pendent amine. The catalytic performance of 2 a–e and 4 were assessed in the cyclization of 2-ethynyl aniline and 2-ethynylbenzyl alcohol. It was revealed that the positioning of the pendent amine near the metal active site is essential for high catalyst performance. A comparison of PPh2NR′2 catalysts (2 a–e) showed minimal difference in performance as a function of pendent amine basicity. Rather, only a threshold basicity – in which the pendent amine was more basic than the substrate – was required for high performance.

Microwave-assisted synthesis of organophosphorus compounds

Kabachnik-Fields reactions of a variety of amines, phospha-Michael additions to maleimide derivatives and alcoholysis of dialkyl phosphites were studied under microwave conditions.

Reprint of Bis(phosphinomethyl)phenylamines and bis(phosphinomethyl) sulfides and their reaction with d8-platinum group precursors

The potentially tridentate phosphines R2PCH2XCH 2PR2 [X = NPh, R = Ph (1), tBu (2), Cy (3), X = S, R = Ph (4), tBu (5)] were treated with different Pd(II), Pt(II) as well as Rh(I) and Ir(I)

N-Benzyl and N-aryl bis(phospha-Mannich adducts): Synthesis and catalytic activity of the related bidentate chelate platinum complexes in hydroformylation

The microwave-assisted double Kabachnik-Fields (phospha-Mannich) reaction of benzylamine and arylamines, two equivalents of paraformaldehyde and the P(O)H reagent, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide gave the bis(P(O)CH2)amine derivatives in good yields. The bis(diphenylphosphinoxido) derivatives were converted to the corresponding ring platinum complexes after deoxygenation whose catalytic activity was tested in the hydroformylation of styrene. Crystal structure analysis of one of the complexes reveals interesting correlations between complex structure and solvent inclusion.

Bis(phosphinomethyl)phenylamines and bis(phosphinomethyl)sulfides and their reaction with d8-platinum group precursors

The potentially tridentate phosphines R2PCH2XCH 2PR2 [X = NPh, R = Ph (1), tBu (2), Cy (3), X = S, R = Ph (4), tBu (5)] were treated with different Pd(II), Pt(II) as well as Rh(I) and Ir(I)

PCNCP ligands in the chromium-catalyzed oligomerization of ethylene: Triversus tetramerization

Chromium(III) complexes bearing R'N(CH2PR2) 2 (PCNCP) ligands have been prepared. Upon activation with methylaluminoxane, these complexes proved to be effective in the selective tri- and tetramerization of ethylene. The fo

Tricarbonylrhenium(I) complexes of phosphine-derivatized amines, amino acids and a model peptide: Structures, solution behavior and cytotoxicity

Modified Mannich reactions of amines, amino acids and a model peptide with Ph2PH and CH2O gave bis(disphenylphosphinomethyl) amines(Ph2PCH2)2NR [R = Ph (1), CH2CH2OH(2), CH2COOCH2Ph (3), CH2CONHCH2COOCH2Ph (4). CH2COOH (5)] and [ReBr(CO)3(Ph2PCH2)2NCH 2]2 (12). All new complexes have been characterized by NMR and IR spectroscopy and for 7, 9 and 10, single-crystal X-ray diffraction analyses. Electrospray mass spectrometric studies show that the rhenium-phosphine chelates are very stable especially in neutral methanolic solution. Hydrolysis of the ester and amide linkages slowly occur in acidic and basic solutions over several weeks; displacement of the bromide ligand also occurs in basic medium. Cytotoxicity testing of 7-10 and 12 showed that all the complexes are active againts specific tumor cell lines, especially MCF-7 breast cancer and HeLa-S3 suspended eturine carcinoma.

Substituent effects in the rhodium catalyzed hydroformylation of olefins using bis(diarylphosphino)methylamino ligands

Rhodium-complexes of bis(diarylphosphino)methylamino ligands RN(CH2PPh2)2 are active catalysts in the hydroformylation of 1-octene and 2-vinylnaphthalene, regioselectivity (n/iso-ratio) and catalyst activity (TOF) depending upon the nature of the para-substituent in the N-aryl moiety (R = C6H5, p-CF3-C6H4, P-NMe2-C6H4).