129887-46-3

Upstream product

• 129887-45-2 ethyl 6-(p-methoxyphenyl)-6-hydroxyhexanoate 
• 64-17-5 ethanol 
• 81077-29-4 (E)-6-(4-methoxyphenyl)pent-5-enoic acid 
• 42916-80-3 ethyl 6-(4-methoxyphenyl)-6-oxohexanoate 
• 637-69-4 4-Methoxystyrene 
• 2969-81-5 Ethyl 4-bromobutyrate 
• 100-66-3 methoxybenzene 
• 626-86-8 adipinic acid monoethyl ester 
• 1071-71-2 ethyl 6-chloro-6-oxohexanoate 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 

Downstream Products

• 128577-60-6 (5E)-6-(4-Methoxyphenyl)-5-hexen-1-ol 
• 128622-55-9 (E)-6-(p-methoxyphenyl)-5-hexenyl 9-phenanthrenecarboxylate 
• 129887-63-4 (Z)-6-(p-methoxyphenyl)-5-hexenyl 9-phenanthrenecarboxylate 
• 197707-75-8 methyl-3-{5-[3-(mmethoxycarbonyl)benzoylamino]-2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenyl}propanoate 
• 197707-86-1 ethyl-4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoate 
• 197707-76-9 methyl-4-{3-(2-ethoxycarbonylethyl)-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate 
• 197707-80-5 methyl 4-{3-[2-(dimethylaminocarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminocarbonyl}butanoate 
• 134577-71-2 t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-(4-methoxycarbonylbutanamido)benzen-2-yl]propionate 
• 197707-87-2 4-{3-[2-(tert-butoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylaminosulfonyl}butanoic acid 
• 134577-74-5 t-Butyl 3-[1-[6-(4-methoxyphenyl)hex-5E-enyl]oxy-4-(5-hydroxypentanamido)benzen-2-yl]propionate 
• 197707-73-6 ethyl-3-{2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]-5-n-heptanoylaminophenyl}propanoate 
• 134577-72-3 4-{3-(2-tert-Butoxycarbonyl-ethyl)-4-[(E)-6-(4-methoxy-phenyl)-hex-5-enyloxy]-phenylcarbamoyl}-butyric acid 
• 197707-85-0 tert-butyl-3-{2-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]-5-(4-methylphenyl)sulfonylaminophenyl}propanoate 
• 197707-94-1 ethyl-4-{3-[2-(ethoxycarbonyl)ethyl]-4-[6-(4-methoxyphenyl)-(5E)-hexenyloxy]phenylcarbonyl}butanoate 

Relevant academic research and scientific papers

Irradiation-Induced Heck Reaction of Unactivated Alkyl Halides at Room Temperature

The palladium-catalyzed Mizoroki-Heck reaction is arguably one of the most significant carbon-carbon bond-construction reactions to be discovered in the last 50 years, with a tremendous number of applications in the production of chemicals. This Nobel-Prize-winning transformation has yet to overcome the obstacle of its general application in a range of alkyl electrophiles, especially tertiary alkyl halides that possess eliminable β-hydrogen atoms. Whereas most palladium-catalyzed cross-coupling reactions utilize the ground-state reactivity of palladium complexes under thermal conditions and generally apply a single ligand system, we report that the palladium-catalyzed Heck reaction proceeds smoothly at room temperature with a variety of tertiary, secondary, and primary alkyl bromides upon irradiation with blue light-emitting diodes in the presence of a dual phosphine ligand system. We rationalize that this unprecedented transformation is achieved by utilizing the photoexcited-state reactivity of the palladium complex to enhance oxidative addition and suppress undesired β-hydride elimination.

Trisubstituted benzene leukotriene B4 receptor antagonists: Synthesis and structure-activity relationships

A series of trisubstituted benzenes which demonstrate leukotriene B4 (LTB4, 1) receptor affinity was prepared. Previous trisubstituted benzenes from our laboratory showed high affinity to the LTB4 receptor but demonstrated