1299293-53-0

Basic information

• Product Name: O,O-dimethyl α-(2,4-dibromophenoxyacetoxy)ethylphosphonate
• Synonyms: O,O-dimethyl α-(2,4-dibromophenoxyacetoxy)ethylphosphonate
• CAS NO: 1299293-53-0
• Molecular Weight: 446.029
• Mol File: 1299293-53-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: O,O-dimethyl α-(2,4-dibromophenoxyacetoxy)ethylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: O,O-dimethyl α-(2,4-dibromophenoxyacetoxy)ethylphosphonate(1299293-53-0)
• EPA Substance Registry System: O,O-dimethyl α-(2,4-dibromophenoxyacetoxy)ethylphosphonate(1299293-53-0)

Safety Data

• Hazardous Substances Data: 1299293-53-0(Hazardous Substances Data)

Upstream product

• 10129-78-9 2-(2,4-dibromophenoxy)acetic acid 
• 615-58-7 2,4-dibromophenol 
• 10184-66-4 dimethyl (1-hydroxyethyl)phosphonate 
• 16738-07-1 2,4-dibromophenoxyacetyl chloride 

Relevant articles and documents

Studies of O,O-Dimethyl α-(2,4-Dichlorophenoxyacetoxy) ethylphosphonate (HW02) as a new herbicide. 1. Synthesis and herbicidal activity of HW02 and analogues as novel inhibitors of pyruvate dehydrogenase complex

On the basis of the previous work for optimization of O,O-diethyl α-(substituted phenoxyacetoxy)alkylphosphonates, further extensive syntheticmodifications were made to the substituents in alkylphosphonate and phenoxymoieties of the title compounds. New O,O-dimethyl α-(substituted phenoxyacetoxy)alkylphosphonates were synthesized as potential inhibitors of pyruvate dehydorogenase complex (PDHc). Their herbicidal activity and efficacy in vitro against PDHc were examined. Some of these compounds exhibited significant herbicidal activity and were demonstrated to be effective inhibitors of PDHc from three different plants. The structure-activity relationships of these compounds including previously reported analogous compoundswere studied by examining their herbicidal activities. Both inhibitory potency against PDHc and herbicidal activity of title compounds could be increased greatly by optimizing substituent groups of the title compounds. O,O-Dimethyl α-(2,4- dichlorophenoxyacetoxy)ethylphosphonate (I-5), which acted as a competitive inhibitor of PDHc with much higher inhibitory potency against PDHc from Pisum sativum and Phaseolus radiatus than from Oryza sativa, was found to be themost effective compound against broadleaf weeds and showed potential utility as herbicide.