615-58-7Relevant articles and documents
Halogenated method of aromatic compound
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Paragraph 0205-0207, (2021/11/10)
The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.
Preparation method of monobrominated aromatic hydrocarbon compound
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Paragraph 0071-0074, (2020/11/23)
The invention discloses a preparation method of a monobrominated aromatic hydrocarbon compound, which comprises the following steps: by using an aromatic hydrocarbon compound as a raw material, wateras a solvent and liquid bromine as a bromine source, reacting at room temperature for 4.5 hours, and after the reaction is finished, carrying out aftertreatment on the obtained reaction mixed solutionto obtain the monobrominated target product. According to the method, a high-selectivity bromination method is realized on the aromatic hydrocarbon compound under the action of water, and the monobrominated aromatic hydrocarbon compound is prepared. The method is high in reaction applicability, mild in condition, high in yield, green and environment-friendly.
Mild and Regioselective Bromination of Phenols with TMSBr
Ma, Xiantao,Yu, Jing,Jiang, Mengyuan,Wang, Mengyu,Tang, Lin,Wei, Mengmeng,Zhou, Qiuju
supporting information, p. 4593 - 4596 (2019/07/05)
In this work, an unexpected promoting effect of by-product thioether was observed, leading to a mild and regioselective bromination of phenols with TMSBr. This method can tolerate a series of functional groups such as the reactive methoxyl, amide, fluoro, chloro, bromo, aldehyde, ketone and ester groups, and has the potential to recycle the by-product thioether and isolate the desired product under column chromatography-free conditions. Mechanism studies revealed that O–H···S hydrogen bond may be formed between phenol and by-product thioether. Possibly owing to the steric hindrance effect from by-product thioether, the electrophilic bromination at para-position of phenols is much favorable.
