1299469-67-2Relevant articles and documents
Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium
Behnken, Swantje,Lincke, Thorger,Kloss, Florian,Ishida, Keishi,Hertweck, Christian
, p. 2425 - 2428 (2012)
Anti-Terminator: Rise of the Molecules: Overexpression of an antiterminator gene (nusG) in Clostridium cellulolyticum induced the biosynthesis of the novel antibiotic closthioamide and related thioamides. This is the first successful genetic engineering of an anaerobe to trigger a cryptic pathway. Furthermore, synthetic probes provide valuable insights into the biogenetic relationship of the rare thioamide metabolites. Copyright
CLOSTHIOAMIDES
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Page/Page column 29, (2011/05/11)
This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent.