130-84-7 Usage
Uses
Used in Pharmaceutical Industry:
DIMETHYL (Z)-2,3-DIACETYLOXYBUT-2-ENEDIOATE is used as a key intermediate in the synthesis of HIV-1 integrase inhibitors. These inhibitors are crucial in the development of antiretroviral drugs, which are essential for the treatment of HIV/AIDS. The compound's ability to form specific chemical bonds and its reactivity make it a valuable component in the creation of these life-saving medications.
Check Digit Verification of cas no
The CAS Registry Mumber 130-84-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 0 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 130-84:
(5*1)+(4*3)+(3*0)+(2*8)+(1*4)=37
37 % 10 = 7
So 130-84-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H12O8/c1-5(11)17-7(9(13)15-3)8(10(14)16-4)18-6(2)12/h1-4H3/b8-7-
130-84-7Relevant academic research and scientific papers
Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold
Jones, Eric D.,Vandegraaff, Nick,Le, Giang,Choi, Neil,Issa, William,MacFarlane, Katherine,Thienthong, Neeranat,Winfield, Lisa J.,Coates, Jonathan A.V.,Lu, Long,Li, Xinming,Feng, Xiao,Yu, Changjiang,Rhodes, David I.,Deadman, John J.
scheme or table, p. 5913 - 5917 (2010/11/18)
HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells.
