133-47-1

Usage

Uses

Dihydroxyfumaric Acid Dimethyl Ester is used in the reactions involving of β-sheet formation.

Synthesis Reference(s)

The Journal of Organic Chemistry, 33, p. 4004, 1968 DOI: 10.1021/jo01275a002

InChI:InChI=1/C6H8O6/c1-11-5(9)3(7)4(8)6(10)12-2/h7,9H,1-2H3/b5-3-

Upstream product

• 67-56-1 methanol 
• 133-38-0 dihydroxyfumaric acid 
• 16852-01-0 dimethyl 2,3-dioxobutanedioate 
• 20389-20-2 Octahydroxycyclobutane 
• 7732-18-5 water 
• 86212-16-0 C₄(OOBC₆H₅)2(OCH₃)4 
• 86212-11-5 1,2:2,3:3,4:4,1-tetrakis[propylboranediylbis(oxy)]cyclobutane 
• 186581-53-3 diazomethane 

Downstream Products

• 130-84-7 DAF 
• 72030-81-0 dimethyl oxazole-4,5-dicarboxylate 
• 17540-28-2 Dimethyl-bis-(3-chlor-anilino)-maleat 
• 17540-29-3 Dimethyl-bis-(3,4-dichlor-anilino)-maleat 
• 1036646-05-5 6-hydroxy-7-oxo-3-phenyl-1,7-dihydro-pyrazolo[1,5-a]pyrimidine-5-carboxylic acid methyl ester 
• 910868-11-0 C₁₈H₁₆F₂N₂O₄ 
• 17540-26-0 Dimethyl-bis-(4-fluor-anilino)-maleat 
• 17540-27-1 Dimethyl-bis-(4-chlor-anilino)-maleat 
• 17540-25-9 Bis-(p-tolyl-amino)-ethylendicarbonsaeure-dimethylester 
• 54107-99-2 dimethyl quinoxaline-2,3-dicarboxylate 

Relevant academic research and scientific papers

Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold

HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC50 of 3 nM against wild type HIV infected T-cells.

BICYCLIC PYRIMIDINONES AND USES THEREOF

The present invention provides a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. Further provided is a method of treatment or prophylaxis of a viral infection in a subject comprising administering to said subject an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative, salt or prodrug thereof. A pharmaceutical composition or medicament comprising a compoundof Formula I is also provided.

PREPARATION AND DIELS-ALDER CYCLOADDITIONS OF SUBSTITUTED VINYLENE CARBONATES (1,3-DIOXOL-2-ONES) AND RELATED COMPOUNDS

Several substituted vinylene carbonates have been prepared by efficient routes and the dienophilicity of these and related compounds in Diels-Alder cycloadditions has been evaluated.

Hydrated Oxocarbons, I. Preparation and Reactions of Tetrakiscyclobutanes

Octahydroxycyclobutane (1) reacts with various monoorganoboranes to give in high yields the tetrakis derivatives 2a - d.These react with tertiary amines to yield either 1:2 or 1:4 adducts.Depending on the organo substituents at the boron atoms, alcoholyses of 2a - d result in either partial or complete deborylation giving e.g. tetraalkoxybis derivatives of the cyclobutane ring (7b, c), or, with ring-opening, dimethyl dihydroxyfumarate (5).