1300-94-3 Usage
Chemical Properties
Clear or almost clear liquid, or solid crystalline mass, colourless or slightly yellow when freshly prepared. The substance changes colour during storage by darkening and/or discolouration to dark yellow, brownish-yellow or pink.
Uses
Antiseptic. Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections,. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition.
Definition
ChEBI: Amylmetacresol is a phenol having the structure of m-cresol substituted at the 6-position with an amyl group. It has a role as an antiseptic drug. It derives from a m-cresol.
Mode of action
The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action. Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner.
Check Digit Verification of cas no
The CAS Registry Mumber 1300-94-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,0 and 0 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1300-94:
(6*1)+(5*3)+(4*0)+(3*0)+(2*9)+(1*4)=43
43 % 10 = 3
So 1300-94-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18O/c1-3-4-5-6-11-8-7-10(2)9-12(11)13/h7-9,13H,3-6H2,1-2H3
1300-94-3Relevant articles and documents
EFFICIENT AND COST-EFFECTIVE PROCESS FOR THE MANUFACTURE OF AMYL M-CRESOL
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Page/Page column 32; 36, (2012/02/15)
There is described a process for the preparation of amyl-m-cresol (AMC) which comprises the steps of; (i) reaction of m-cresol with valeric acid, or a derivative thereof, (to form m- cresol valerate (3-toluoyl valerate)); (ii) rearrangement, optionally in situ, of 3-toluoyl valerate in the presence of an oxoacid, provided that the oxoacid is not a carboxylic acid or nitric acid; and (iii) reduction of valeryl m-cresol (VMC), e.g. using a palladium on charcoal catalyst and hydrogen.
