1300031-57-5

Basic information

• Product Name: 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide
• Synonyms: 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide
• CAS NO: 1300031-57-5
• Molecular Weight: 331.758
• Mol File: 1300031-57-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide(1300031-57-5)
• EPA Substance Registry System: 4-chloro-7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-quinolinecarboxamide(1300031-57-5)

Safety Data

• Hazardous Substances Data: 1300031-57-5(Hazardous Substances Data)

Upstream product

• 1300031-58-6 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid 
• 1300031-59-7 C₁₈H₁₈N₂O₅ 
• 1300031-58-6 7-(3,5-dimethyl-4-isoxazolyl)-4-hydroxy-6-(methyloxy)-3-quinolinecarboxylic acid 
• 1300031-59-7 ethyl 7-(3,5-dimethyl-4-isoxazolyl)-4-hydroxy-6-(methyloxy)-3-quinolinecarboxylate 
• 1300031-60-0 1,3-diethyl 2-([[3-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methoxyphenyl]amino]methylidene)propanedioate 
• 1300031-61-1 [3-(3,5-dimethyl-4-isoxazolyl)-4-(methyloxy)phenyl]amine 
• 1300031-62-2 3,5-dimethyl-4-[2-(methyloxy)-5-nitrophenyl]isoxazole 
• 5399-03-1 2-iodo-1-methoxy-4-nitrobenzene 
• 16114-47-9 3,5-dimethylisoxazole-4-boronic acid 

Downstream Products

• 1300737-69-2 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-4-{[(1R)-1-(2-pyridinyl)ethyl]amino}-3-quinolinecarboxamide 
• 1300031-49-5 I-BET151 
• 1300735-18-5 C₂₂H₁₇FN₄O₃ 
• 1373354-29-0 C₂₈H₃₁N₅O₄ 
• 1373354-30-3 C₂₈H₂₃N₅O₄ 
• 1372132-40-5 C₂₂H₁₉FN₄O₃ 
• 1373354-32-5 C₂₆H₂₇N₅O₄ 
• 1373354-33-6 C₂₈H₂₉N₅O₄ 
• 1373354-27-8 C₂₆H₂₈N₄O₃ 
• 1372132-46-1 C₂₂H₂₆N₄O₃ 
• 1403491-64-4 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-2-(1-piperidinyl)-1H-imidazo[4,5-c]quinoline 
• 1403491-63-3 7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-2-(4-morpholinyl)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinoline 
• 1403491-47-3 2-({7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinolin-2-yl}amino)ethanol 
• 1403491-35-9 2-chloro-7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1-[(1R)-1-phenylethyl]-1H-imidazo[4,5-c]quinoline 

Relevant articles and documents

METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE

The present disclosure relates to compounds and methods for modulating the expression of dmpk, and treating diseases and conditions in which dmpk plays an active role. The compound can be a transcription modulator molecule having a first terminus, a second terminus, and oligomeric backbone, wherein: a) the first terminus comprises a DNA-binding moiety capable of noncovalently binding to a nucleotide repeat sequence CAG or CTG; b) the second terminus comprises a protein-binding moiety binding to a regulatory molecule that modulates an expression of a gene comprising the nucleotide repeat sequence CAG or CTG; and c) the oligomeric backbone comprising a linker between the first terminus and the second terminus.

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151

The discovery, synthesis and biological evaluation of a novel series of 7-isoxazoloquinolines is described. Several analogs are shown to increase ApoA1 expression within the nanomolar range in the human hepatic cell line HepG2.

NOVEL COMPOUNDS

Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.