130006-19-8

Basic information

• Product Name: [5-[4-[(1-methyl4H-pyridine-3-carbonyl)amino]-2-oxo-pyrimidin-1-yl]oxo lan-2-yl]methyl 1-methyl-4H-pyridine-3-carboxylate
• Synonyms: [5-[4-[(1-methyl4H-pyridine-3-carbonyl)amino]-2-oxo-pyrimidin-1-yl]oxo lan-2-yl]methyl 1-methyl-4H-pyridine-3-carboxylate;5',4N-bis((1,4-dihydro-1-methyl-3-pyridinyl)carbonyl)-2',3'-dideoxycytosine
• CAS NO: 130006-19-8
• Molecular Formula: C23H27N5O5
• Molecular Weight: 0
• Mol File: 130006-19-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.36g/cm³
• Refractive Index: 1.648
• CAS DataBase Reference: [5-[4-[(1-methyl4H-pyridine-3-carbonyl)amino]-2-oxo-pyrimidin-1-yl]oxo lan-2-yl]methyl 1-methyl-4H-pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: [5-[4-[(1-methyl4H-pyridine-3-carbonyl)amino]-2-oxo-pyrimidin-1-yl]oxo lan-2-yl]methyl 1-methyl-4H-pyridine-3-carboxylate(130006-19-8)
• EPA Substance Registry System: [5-[4-[(1-methyl4H-pyridine-3-carbonyl)amino]-2-oxo-pyrimidin-1-yl]oxo lan-2-yl]methyl 1-methyl-4H-pyridine-3-carboxylate(130006-19-8)

Safety Data

• Hazardous Substances Data: 130006-19-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H27N5O5/c1-26-10-3-5-16(13-26)21(29)24-19-9-12-28(23(31)25-19)20-8-7-18(33-20)15-32-22(30)17-6-4-11-27(2)14-17/h3-4,9-14,18,20H,5-8,15H2,1-2H3,(H,24,25,29,31)

Upstream product

• 7481-89-2 2`,3`-dideoxycytidine 
• 6138-42-7 3-Carboxy-1-methylpyridiniumiodid 

Relevant articles and documents

Synthesis and Pharmacokinetics of a Dihydropyridine Chemical Delivery System for the Antiimmunodeficiency Virus Agent Dideoxycytidine

In order to explore the possibility that a dihydropyridine/pyridinium redox chemical delivery system might enhance significantly the brain uptake of the anti-HIV agent dideoxycytidine (DDC), we prepared a DDC derivative wihich bore the 1,4-dihydro-1-methyl-3-pyridylcarbonyl moiety at both the cytidine exocyclic amino moiety and the sugar 5'-hydroxyl function; namely 5',4N-bis-2',3'-dideoxycytidine (2).In cell-free extracts of rat brain tissue, compound 2 was readily converted to free DDC by stepwise oxidation and hydrolysis of the dihydropyridyl groups.Time-dependent plasma and brain concentrations of DDC and 2 were determined following iv administration of 2 (49.3 mg/kg) to rats.Compound 2 could be detected in brain, reaching peak concentrations of 7.7 +/- 2.9 nmol/g at 15 min.Low levels of DDC also were detected with a peak concentration of 1.4 +/- 0.5 nmol/g at 240 min after injection.The brain/plasma concentration integral of compound 2 was 0.95 whereas that for DDC in brain as a ratio of combined DDC and compound 2 levels in plasma was 0.24.Despite this, brain concentrations remained low and not significantly different from those achieved following administration of DDC alone.