1300087-15-3

Basic information

• Product Name: benzyl (8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate
• CAS NO: 1300087-15-3
• Molecular Weight: 457.919
• Mol File: 1300087-15-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl (8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate(1300087-15-3)
• EPA Substance Registry System: benzyl (8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)carbamate(1300087-15-3)

Safety Data

• Hazardous Substances Data: 1300087-15-3(Hazardous Substances Data)

Upstream product

• 124676-19-3 2-(benzotriazol-1-yl)-N-(benzyloxycarbonyl)glycine 
• 155452-87-2 (3RS)-3-benzyloxycarbonylamino-7-chloro-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 676127-91-6 [benzotriazol-1-yl(2-benzoyl-4-chloro-phenylcarbamoyl)-methyl]-carbamic acid benzyl ester 
• 1300089-51-3 benzyl (7-chloro-5-phenyl-2-thioxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate 

Relevant articles and documents

Discovery of epigenetic regulator i-bet762: Lead optimization to afford a clinical candidate inhibitor of the bet bromodomains

The bromo and extra C-terminal domain (BET) family of bromodomains are involved in binding epigenetic marks on histone proteins, more specifically acetylated lysine residues. This paper describes the discovery and structure-activity relationships (SAR) of potent benzodiazepine inhibitors that disrupt the function of the BET family of bromodomains (BRD2, BRD3, and BRD4). This work has yielded a potent, selective compound I-BET762 that is now under evaluation in a phase I/II clinical trial for nuclear protein in testis (NUT) midline carcinoma and other cancers.