130056-75-6Relevant academic research and scientific papers
Synthesis and Stereochemistry of rac.-trans-Tetrahydro-6-hydroxy-7-(4-methoxyphenyl)-1,4-thiazepin-5(2H)-one
Mohacsi, Erno,O'Brien, Jay P.,Todaro, Louis J.
, p. 1085 - 1089 (2007/10/02)
The base catalyzed reaction of 2-aminoethanethiol (3) with trans-3-(p-methoxyphenyl)glycidate (4) gave a mixture of isomeric lactams 5 and 6, and in addition, a by-product 7.The structures of these isomers were proven by X-ray crystallography.The data revealed that both isomers adopt the chair conformation in the solid state and the size of the heterocyclic ring in compound 5 is a six- and in compound 6 is a seven-membered ring.
