1300581-80-9

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 103-82-2 phenylacetic acid 
• 343-59-9 1-(5-fluoro-2-hydroxyphenyl)-2-phenylethanone 
• 123-62-6 propionic acid anhydride 

Downstream Products

• 1300581-82-1 2-(1-Bromoethyl)-6-fluoro-3-phenyl-4H-chromen-4-one 
• 1300585-03-8 2-(1-(4-amino-3-(3-methyl-1H-indazol-6-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-phenyl-4H-chromen-4-one 
• 1300583-92-9 2-(1-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-phenyl-4H-chromen-4-one 
• 1300583-43-0 2-(1-(6-Amino-9H-purin-9-yl)ethyl)-6-fluoro-3-phenyl-4H-chromen-4-one 

Relevant academic research and scientific papers

Preparation method and application of flavone and isoflavone compound

The invention provides a preparation method of a flavone and isoflavone compound, wherein the reaction formula is defined in the specification. The preparation method specifically comprises the following steps: in an inert gas atmosphere, taking a compound as shown in a formula A, B and C as initial raw materials, carrying out a stirring reaction in a solvent H under the action of a palladium catalyst D, a phosphine ligand E, norbornene F and an alkali G, and separating to obtain the flavone and isoflavone compound M, J, K or L. According to the invention, the main raw materials involved in the method are all commercial reagents and are low in price, the catalyst is a norbornene derivative, and compared with a catalyst norbornene used in similar reactions in the prior art, the dosage of the norbornene derivative is greatly reduced, the preparation cost is reduced, and the method is suitable for industrial production. The invention also provides an application of the prepared flavone and isoflavone compound in the preparation of a umbralisib core skeleton.

NOVEL KINASE MODULATORS

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.