130064-23-2Relevant academic research and scientific papers
Synthesis and post-coital contraceptive activity of a new series of substituted 2,3-diaryI-2H-1-benzopyrans
Hajela,Kapil
, p. 135 - 142 (2007/10/03)
A series of substituted 2,3-diaryl-2H-1-benzopyrans have been synthesized and screened for their post-coital contraceptive activity in rats. Most of the compounds showed 100% inhibition in a single day schedule at a dose level of 1.0 mg/kg. Compound 32 was found to be the most active with a minimum effective dose (MED) of 0.2 mg/kg in single day testing. Further, it also showed high antiestrogenic activity and is devoid of any agonistic activity.
Structure-Activity Relationship of Antiestrogens. Phenolic Analogues of 2,3-Diaryl-2H-1-benzopyrans
Sharma, Arun P.,Saeed, Ashraf,Durani, Susheel,Kapil, Randhir S.
, p. 3222 - 3229 (2007/10/02)
Phenolic analogues of 2--3-phenyl-2H-1-benzopyran (1), a novel antiestrogen, were synthesized and evaluated for their structure-activity relationship.Incorporation of OH at position 7 was found to improve receptor affinity of
