130064-36-7

Basic information

• Product Name: 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-
• Synonyms: CDRI 86/333
• CAS NO: 130064-36-7
• Molecular Formula: C28H29 N O4
• Molecular Weight: 443.543
• Mol File: 130064-36-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-(130064-36-7)
• EPA Substance Registry System: 2H-1-Benzopyran-7-ol,3-(4-hydroxyphenyl)-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-(130064-36-7)

Safety Data

• Hazardous Substances Data: 130064-36-7(Hazardous Substances Data)

Upstream product

• 2008-75-5 N-chloroethylpiperidine hydrochloride 
• 130064-34-5 2-(4-hydroxyphenyl)-3-<4-<(tetrahydropyran-2-yl)oxy>phenyl>-7-<(tetrahydropyran-2-yl)oxy>-2H-1-benzopyran 
• 17720-60-4 2,4,4'-trihydroxy deoxybenzoin 
• 173676-53-4 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenoxy-2H-chromene 
• 173676-52-3 4-{7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2H-chromen-2-yl}-phenol 
• 173676-31-8 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2H-chromen-2-ol 
• 173676-30-7 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-chromen-2-one 
• 3173-00-0 7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one 
• 3040-44-6 1-piperidinoethanol 
• 690274-19-2 3-(4-hydroxy-phenyl)-2-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-7-(tetrahydro-pyran-2-yloxy)-chroman-4-one 

Relevant articles and documents

Estrogen receptor ligands. Part 1: The discovery of flavanoids with subtype selectivity

A class of flavanoids exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The most active analogue 6 was found to be 66-fold ERα-selective and demonstrated uterine estradiol antagonism.

Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans

A method of inhibiting bone loss comprising administering to an animal an effective amount of a compound having the formula STR1 wherein: R1 and R2 are, independently, --H, --OH, halo, --OC1 -C17 alkyl, --OC3 -C6 cycloalkyl, --O(CO)C1 -C17 alkyl, --O(CO) aryl, --O(CO)O aryl, or --OSO2 -(n-butyl or n-pentyl); R3 is STR2 R4 is --H, methyl, ethyl, propyl, ethenyl or ethynyl; or a pharmaceutically acceptable salt or solvate thereof.

Benzopyrans as antiestrogenic agents

The present invention provides compounds of formula (I) wherein R1 and R2, which may be the same or different, are each -H, -OH, alkoxy of 1 to 17 carbon atoms or alkoxycarbonyl of 2 to 18 carbon atoms and R3 is are useful in the treatment of an estrogen dependent condition such as breast cancer.