1300731-90-1Relevant articles and documents
Molecular design, synthesis and biological research of novel pyridyl acridones as potent DNA-binding and apoptosis-inducing agents
Zhang, Bin,Chen, Kang,Wang, Ning,Gao, Chunmei,Sun, Qinsheng,Li, Lulu,Chen, Yuzong,Tan, Chunyan,Liu, Hongxia,Jiang, Yuyang
, p. 214 - 226 (2015)
A series of novel pyridyl acridone derivatives comprised of a pseudo-five-cyclic system to extend the π-conjugated acridone chromophore, were designed and synthesized as potent DNA binding antitumor compounds. Most synthesized compounds displayed good act
Polysubstitution phenyl alkyl amino acridine-4-amide compound and preparing method and purpose thereof
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Paragraph 0155; 0156, (2016/10/10)
The invention provides a polysubstitution phenyl alkyl amino acridine-4-amide compound and a preparing method and purpose thereof. The compound is the polysubstitution phenyl alkyl amino acridine-4-amide compound having the structural formula shown as the formula I or salt or ester or solvate acceptable in pharmacy, wherein R1, R2, R3 and n are defined in the description. The compound can effectively inhibit expression of Survivin protein in tumor cells, inhibit activity of DNA topoisomerase, inhibit eukaryote tumor cell proliferation and prevent and/or treat tumor.
Radiosynthesis and in vivo evaluation of 1-[18F]fluoroelacridar as a positron emission tomography tracer for P-glycoprotein and breast cancer resistance protein
D?rner, Bernd,Kuntner, Claudia,Bankstahl, Jens P.,Wanek, Thomas,Bankstahl, Marion,Stanek, Johann,Müllauer, Julia,Bauer, Florian,Mairinger, Severin,L?scher, Wolfgang,Miller, Donald W.,Chiba, Peter,Müller, Markus,Erker, Thomas,Langer, Oliver
experimental part, p. 2190 - 2198 (2011/05/13)
Aim of this study was to label the potent dual P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor elacridar (1) with 18F to provide a positron emission tomography (PET) radiotracer to visualize Pgp and BCRP. A series of
