130075-13-7

Upstream product

• 109462-20-6 1-methyl hydrogen 3-<(tert-butyl)dimethylsilyloxy>glutarate 
• 622-33-3 N-benzyloxyamine 
• 131352-62-0 methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-hydroxybutyrate 
• 130075-12-6 β-<(tert-butyldimethylsilyl)oxy>-δ-hydroxypimelic acid, N-(benzyloxy)amide monomethyl ester 
• 130075-11-5 β-<(tert-butyldimethylsilyl)oxy>-δ-oxopimelic acid, methyl benzyl diester 
• 133374-67-1 methyl 4-<1-(benzyloxy)-2-oxo-4-azetidinyl>-β-<(tert-butyldimethylsilyl)oxy>butyrate 
• 131352-56-2 β-<(tert-butyldimethylsilyl)oxy>-δ-hydroxypimelic acid, methyl benzyl diester 

Downstream Products

• 130075-10-4 methyl 4-<1-(benzyyloxy)-2-oxo-4-azetidinyl>α-diazo-β-ketobutyrate 
• 131352-67-5 ((1R,5R)-3-Oxo-6-phenylcarbamoyl-2,7-dioxa-6-aza-bicyclo[3.2.1]oct-1-yl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Novel benzoic and phenylacetic acid derivatives

The compound of the formula STR1 wherein R1, R2 and R3 have the significance given in the description, can be used as medicaments for the therapy and prophylaxis of disorders such as thromboses, stroke, cardiac infarct, inflammations and arteriosclerosis as well as for the treatment of tumours.

SYNTHESIS OF THE CARBAPENAM RING SYSTEM VIA CARBENE MEDIATED REARRANGEMENT OF AN N-BENZYLOXY-β-LACTAM

The α-diazoester 1 in the presence of catalytic Rh2(OAc)4 was converted to the carbapenam 2.The synthesis of 1 and a proposed mechanism are described.