130106-00-2

Upstream product

• 638-07-3 ethyl (2-chloroaceto)acetate 
• 106-53-6 para-bromobenzenethiol 

Downstream Products

• 1341195-63-8 ethyl 3-hydroxy-4-(phenylsulfonyl)butanoate 
• 1341195-56-9 ethyl 4-[(4-bromophenyl)sulfonyl]-3-oxobutanoate 
• 1227692-39-8 5-((4-bromophenylthio)methyl)-1H-pyrazol-3(2H)-one 
• 835926-46-0 N-(4-benzoimidazol-1-yl-phenyl)-2-(5-cyano-benzo[b]thiophen-3-yl)-3-phenyl-propionamide 
• 835925-81-0 3-(1-benzyl-3-diazo-2-oxo-3-trimethylsilanyl-propyl)-benzo[b]thiophene-5-carbonitrile 
• 835926-54-0 2-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzo[b]thiophen-3-yl]-3-phenyl-propionic acid ethyl ester 
• 835925-86-5 2-[5-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzo[b]thiophen-3-yl]-3-phenyl-propionic acid 
• 835926-45-9 2-(5-cyano-benzo[b]thiophen-3-yl)-3-phenyl-propionic acid ethyl ester 
• 835925-78-5 2-(5-cyano-benzo[b]thiophen-3-yl)-3-phenyl-propionic acid 
• 17266-44-3 ethyl 2-(5-bromobenzo[b]thiophen-3-yl)acetate 

Relevant academic research and scientific papers

Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors

The inhibition of CYP17 to block androgen biosynthesis is a well validated strategy for the treatment of prostate cancer. Herein we reported the design, synthesis and structure–activity relationship (SAR) study for a series of novel 1,2,3,4- tetrahydroben

Substituted benzothieno [2,3-c] tetrahydropyridine derivative and preparation method and application thereof

The invention belongs to the technical field of medicinal chemistry and medicines, and relates to a substituted benzothieno [2,3-c] tetrahydropyridine derivative as shown in formula (I), a preparationmethod of the substituted benzothieno [2,3-c] tetrahydr

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease currently without a cure. Mutations in copper/zinc superoxide dismutase 1 (SOD1) have been implicated in the pathophysiology of this disease. Using a high-throughput screening assa

Ru-catalyzed asymmetric hydrogenation of γ-heteroatom substituted β-keto esters

A series of enantiomerically pure γ-heteroatom substituted β-hydroxy esters were synthesized with high enantioselectivities (up to 99.1% ee) by hydrogenation of γ-heteroatom substituted β-keto esters in the presence of Ru-(S)-SunPhos catalyst. These asymmetric hydrogenations provide key building blocks for a variety of naturally occurring and biologically active compounds.

5-Amidinobenzo[b]thiophenes as dual inhibitors of factors IXa and Xa

Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa potency and equal or slightly better selectivity relative to factor Xa. Syntheses and SAR studies of 5-amidinobenzo[b]thiophene analogs provided compounds with low submicromolar factor IXa activity and equal or slightly better selectivity relative to factor Xa.